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    Targeting the CD27-CD70 Pathway to Improve Outcomes in Both Checkpoint Immunotherapy and Allogeneic Hematopoietic Cell Transplantation

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    Author
    Lutfi, Forat
    Wu, Long
    Sunshine, Sarah
    Cao, Xuefang
    Date
    2021-09-22
    Journal
    Frontiers in Immunology Open Access
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fimmu.2021.715909
    Abstract
    Immune checkpoint inhibitor therapies and allogeneic hematopoietic cell transplant (alloHCT) represent two distinct modalities that offer a chance for long-term cure in a diverse array of malignancies and have experienced many breakthroughs in recent years. Herein, we review the CD27-CD70 co-stimulatory pathway and its therapeutic potential in 1) combination with checkpoint inhibitor and other immune therapies and 2) its potential ability to serve as a novel approach in graft-versus-host disease (GVHD) prevention. We further review recent advances in the understanding of GVHD as a complex immune phenomenon between donor and host immune systems, particularly in the early stages with mixed chimerism, and potential novel therapeutic approaches to prevent the development of GVHD.
    Rights/Terms
    Copyright © 2021 Lutfi, Wu, Sunshine and Cao.
    Keyword
    CD27
    CD70
    allogeneic hematopoietic cell transplant (alloHCT)
    graft-versus-host disease (GVHD)
    immunotherapy
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/16855
    ae974a485f413a2113503eed53cd6c53
    10.3389/fimmu.2021.715909
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