Targeting the CD27-CD70 Pathway to Improve Outcomes in Both Checkpoint Immunotherapy and Allogeneic Hematopoietic Cell Transplantation
Date
2021-09-22Journal
Frontiers in Immunology Open AccessPublisher
Frontiers Media S.A.Type
Article
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Show full item recordAbstract
Immune checkpoint inhibitor therapies and allogeneic hematopoietic cell transplant (alloHCT) represent two distinct modalities that offer a chance for long-term cure in a diverse array of malignancies and have experienced many breakthroughs in recent years. Herein, we review the CD27-CD70 co-stimulatory pathway and its therapeutic potential in 1) combination with checkpoint inhibitor and other immune therapies and 2) its potential ability to serve as a novel approach in graft-versus-host disease (GVHD) prevention. We further review recent advances in the understanding of GVHD as a complex immune phenomenon between donor and host immune systems, particularly in the early stages with mixed chimerism, and potential novel therapeutic approaches to prevent the development of GVHD.Rights/Terms
Copyright © 2021 Lutfi, Wu, Sunshine and Cao.Keyword
CD27CD70
allogeneic hematopoietic cell transplant (alloHCT)
graft-versus-host disease (GVHD)
immunotherapy
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http://hdl.handle.net/10713/16855ae974a485f413a2113503eed53cd6c53
10.3389/fimmu.2021.715909
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