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    Role of miR-2392 in driving SARS-CoV-2 infection

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    Author
    McDonald, J Tyson
    Enguita, Francisco J
    Taylor, Deanne
    Griffin, Robert J
    Priebe, Waldemar
    Emmett, Mark R
    Sajadi, Mohammad M
    Harris, Anthony D
    Clement, Jean
    Dybas, Joseph M
    Aykin-Burns, Nukhet
    Guarnieri, Joseph W
    Singh, Larry N
    Grabham, Peter
    Baylin, Stephen B
    Yousey, Aliza
    Pearson, Andrea N
    Corry, Peter M
    Saravia-Butler, Amanda
    Aunins, Thomas R
    Sharma, Sadhana
    Nagpal, Prashant
    Meydan, Cem
    Foox, Jonathan
    Mozsary, Christopher
    Cerqueira, Bianca
    Zaksas, Viktorija
    Singh, Urminder
    Wurtele, Eve Syrkin
    Costes, Sylvain V
    Davanzo, Gustavo Gastão
    Galeano, Diego
    Paccanaro, Alberto
    Meinig, Suzanne L
    Hagan, Robert S
    Bowman, Natalie M
    Wolfgang, Matthew C
    Altinok, Selin
    Sapoval, Nicolae
    Treangen, Todd J
    Moraes-Vieira, Pedro M
    Vanderburg, Charles
    Wallace, Douglas C
    Schisler, Jonathan C
    Mason, Christopher E
    Chatterjee, Anushree
    Meller, Robert
    Beheshti, Afshin
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    Date
    2021-09-30
    Journal
    Cell Reports
    Publisher
    Elsevier Inc.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1016/j.celrep.2021.109839
    Abstract
    MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation that have a major impact on many diseases and provide an exciting avenue toward antiviral therapeutics. From patient transcriptomic data, we determined that a circulating miRNA, miR-2392, is directly involved with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) machinery during host infection. Specifically, we show that miR-2392 is key in driving downstream suppression of mitochondrial gene expression, increasing inflammation, glycolysis, and hypoxia, as well as promoting many symptoms associated with coronavirus disease 2019 (COVID-19) infection. We demonstrate that miR-2392 is present in the blood and urine of patients positive for COVID-19 but is not present in patients negative for COVID-19. These findings indicate the potential for developing a minimally invasive COVID-19 detection method. Lastly, using in vitro human and in vivo hamster models, we design a miRNA-based antiviral therapeutic that targets miR-2392, significantly reduces SARS-CoV-2 viability in hamsters, and may potentially inhibit a COVID-19 disease state in humans.
    Rights/Terms
    Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
    Keyword
    COVID-19
    SARS-CoV-2
    antiviral therapeutic
    biomarker
    miR-2392
    miRNA
    microRNA
    nanoligomers
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/16852
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.celrep.2021.109839
    Scopus Count
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    UMB Coronavirus Publications
    UMB Open Access Articles

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