Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Author
McDonald, J TysonEnguita, Francisco J
Taylor, Deanne
Griffin, Robert J
Priebe, Waldemar
Emmett, Mark R
Sajadi, Mohammad M
Harris, Anthony D
Clement, Jean
Dybas, Joseph M
Aykin-Burns, Nukhet
Guarnieri, Joseph W
Singh, Larry N
Grabham, Peter
Baylin, Stephen B
Yousey, Aliza
Pearson, Andrea N
Corry, Peter M
Saravia-Butler, Amanda
Aunins, Thomas R
Sharma, Sadhana
Nagpal, Prashant
Meydan, Cem
Foox, Jonathan
Mozsary, Christopher
Cerqueira, Bianca
Zaksas, Viktorija
Singh, Urminder
Wurtele, Eve Syrkin
Costes, Sylvain V
Davanzo, Gustavo Gastão
Galeano, Diego
Paccanaro, Alberto
Meinig, Suzanne L
Hagan, Robert S
Bowman, Natalie M
Wolfgang, Matthew C
Altinok, Selin
Sapoval, Nicolae
Treangen, Todd J
Moraes-Vieira, Pedro M
Vanderburg, Charles
Wallace, Douglas C
Schisler, Jonathan C
Mason, Christopher E
Chatterjee, Anushree
Meller, Robert
Beheshti, Afshin
Date
2021-09-30Journal
Cell ReportsPublisher
Elsevier Inc.Type
Article
Metadata
Show full item recordAbstract
MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation that have a major impact on many diseases and provide an exciting avenue toward antiviral therapeutics. From patient transcriptomic data, we determined that a circulating miRNA, miR-2392, is directly involved with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) machinery during host infection. Specifically, we show that miR-2392 is key in driving downstream suppression of mitochondrial gene expression, increasing inflammation, glycolysis, and hypoxia, as well as promoting many symptoms associated with coronavirus disease 2019 (COVID-19) infection. We demonstrate that miR-2392 is present in the blood and urine of patients positive for COVID-19 but is not present in patients negative for COVID-19. These findings indicate the potential for developing a minimally invasive COVID-19 detection method. Lastly, using in vitro human and in vivo hamster models, we design a miRNA-based antiviral therapeutic that targets miR-2392, significantly reduces SARS-CoV-2 viability in hamsters, and may potentially inhibit a COVID-19 disease state in humans.Rights/Terms
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.Identifier to cite or link to this item
http://hdl.handle.net/10713/16852ae974a485f413a2113503eed53cd6c53
10.1016/j.celrep.2021.109839
Scopus Count
Related articles
- The Great Deceiver: miR-2392's Hidden Role in Driving SARS-CoV-2 Infection.
- Authors: McDonald JT, Enguita FJ, Taylor D, Griffin RJ, Priebe W, Emmett MR, Sajadi MM, Harris AD, Clement J, Dybas JM, Aykin-Burns N, Guarnieri JW, Singh LN, Grabham P, Baylin SB, Yousey A, Pearson AN, Corry PM, Saravia-Butler A, Aunins TR, Sharma S, Nagpal P, Meydan C, Foox J, Mozsary C, Cerqueira B, Zaksas V, Singh U, Wurtele ES, Costes SV, Davanzo GG, Galeano D, Paccanaro A, Meinig SL, Hagan RS, Bowman NM, UNC COVID-19 Pathobiology Consortium, Wolfgang MC, Altinok S, Sapoval N, Treangen TJ, Moraes-Vieira PM, Vanderburg C, Wallace DC, Schisler J, Mason CE, Chatterjee A, Meller R, Beheshti A
- Issue date: 2021 Aug 18
- What is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19?
- Authors: Guterres A, de Azeredo Lima CH, Miranda RL, Gadelha MR
- Issue date: 2020 Nov
- Expression Analyses of MicroRNAs in Hamster Lung Tissues Infected by SARS-CoV-2.
- Authors: Kim WR, Park EG, Kang KW, Lee SM, Kim B, Kim HS
- Issue date: 2020 Nov 30
- Cellular miR-150-5p may have a crucial role to play in the biology of SARS-CoV-2 infection by regulating nsp10 gene.
- Authors: Akula SM, Bolin P, Cook PP
- Issue date: 2022
- Altered microRNA expression in COVID-19 patients enables identification of SARS-CoV-2 infection.
- Authors: Farr RJ, Rootes CL, Rowntree LC, Nguyen THO, Hensen L, Kedzierski L, Cheng AC, Kedzierska K, Au GG, Marsh GA, Vasan SS, Foo CH, Cowled C, Stewart CR
- Issue date: 2021 Jul