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dc.contributor.authorTuteja, Sony
dc.contributor.authorSalloum, Ramzi G
dc.contributor.authorElchynski, Amanda L
dc.contributor.authorSmith, D Max
dc.contributor.authorRowe, Elizabeth
dc.contributor.authorBlake, Kathryn V
dc.contributor.authorLimdi, Nita A
dc.contributor.authorAquilante, Christina L
dc.contributor.authorBates, Jill
dc.contributor.authorBeitelshees, Amber L
dc.contributor.authorCipriani, Amber
dc.contributor.authorDuong, Benjamin Q
dc.contributor.authorEmpey, Philip E
dc.contributor.authorFormea, Christine M
dc.contributor.authorHicks, J Kevin
dc.contributor.authorMroz, Pawel
dc.contributor.authorOslin, David
dc.contributor.authorPasternak, Amy L
dc.contributor.authorPetry, Natasha
dc.contributor.authorRamsey, Laura B
dc.contributor.authorSchlichte, Allyson
dc.contributor.authorSwain, Sandra M
dc.contributor.authorWard, Kristen M
dc.contributor.authorWiisanen, Kristin
dc.contributor.authorSkaar, Todd C
dc.contributor.authorVan Driest, Sara L
dc.contributor.authorCavallari, Larisa H
dc.contributor.authorBishop, Jeffrey R
dc.date.accessioned2021-10-04T17:23:08Z
dc.date.available2021-10-04T17:23:08Z
dc.date.issued2021-09-25
dc.identifier.urihttp://hdl.handle.net/10713/16782
dc.description.abstractThere is growing interest in utilizing pharmacogenetic (PGx) testing to guide antidepressant use, but there is lack of clarity on how to implement testing into clinical practice. We administered two surveys at 17 sites that had implemented or were in the process of implementing PGx testing for antidepressants. Survey 1 collected data on the process and logistics of testing. Survey 2 asked sites to rank the importance of Consolidated Framework for Implementation Research (CFIR) constructs using best-worst scaling choice experiments. Of the 17 sites, 13 had implemented testing and four were in the planning stage. Thirteen offered testing in the outpatient setting, and nine in both outpatient/inpatient settings. PGx tests were mainly ordered by psychiatry (92%) and primary care (69%) providers. CYP2C19 and CYP2D6 were the most commonly tested genes. The justification for antidepressants selected for PGx guidance was based on Clinical Pharmacogenetics Implementation Consortium guidelines (94%) and US Food and Drug Administration (FDA; 75.6%) guidance. Both institutional (53%) and commercial laboratories (53%) were used for testing. Sites varied on the methods for returning results to providers and patients. Sites were consistent in ranking CFIR constructs and identified patient needs/resources, leadership engagement, intervention knowledge/beliefs, evidence strength and quality, and the identification of champions as most important for implementation. Sites deployed similar implementation strategies and measured similar outcomes. The process of implementing PGx testing to guide antidepressant therapy varied across sites, but key drivers for successful implementation were similar and may help guide other institutions interested in providing PGx-guided pharmacotherapy for antidepressant management. © 2021 The Authors.en_US
dc.description.urihttps://doi.org/10.1111/cts.13154en_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofClinical and Translational Scienceen_US
dc.rights© 2021 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of the American Society for Clinical Pharmacology and Therapeutics.en_US
dc.subject.meshAntidepressive Agents--therapeutic useen_US
dc.subject.meshPharmacogenetic Testingen_US
dc.titleMultisite evaluation of institutional processes and implementation determinants for pharmacogenetic testing to guide antidepressant therapyen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/cts.13154
dc.identifier.pmid34562070
dc.source.countryUnited States


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