Show simple item record

dc.contributor.authorOsman, Aya
dc.contributor.authorZuffa, Simone
dc.contributor.authorWalton, Gemma
dc.contributor.authorFagbodun, Elizabeth
dc.contributor.authorZanos, Panos
dc.contributor.authorGeorgiou, Polymnia
dc.contributor.authorKitchen, Ian
dc.contributor.authorSwann, Jonathan
dc.contributor.authorBailey, Alexis
dc.date.accessioned2021-10-01T16:14:26Z
dc.date.available2021-10-01T16:14:26Z
dc.date.issued2021-08-28
dc.identifier.urihttp://hdl.handle.net/10713/16764
dc.description.abstractThe postnatal period is critical for brain and behavioral development and is sensitive to environmental stimuli, such as nutrition. Prevention of weaning from maternal milk was previously shown to cause depressive-like behavior in rats. Additionally, loss of dietary casein was found to act as a developmental trigger for a population of brain opioid receptors. Here, we explore the effect of exposure to milk containing A1 and A2 β-casein beyond weaning. A1 but not A2 β-casein milk significantly increased stress-induced immobility in rats, concomitant with an increased abundance of Clostridium histolyticum bacterial group in the caecum and colon of A1 β-casein fed animals, brain region-specific alterations of μ-opioid and oxytocin receptors, and modifications in urinary biochemical profiles. Moreover, urinary gut microbial metabolites strongly correlated with altered brain metabolites. These findings suggest that consumption of milk containing A1 β-casein beyond weaning age may affect mood via a possible gut-brain axis mechanism.en_US
dc.description.urihttps://doi.org/10.1016/j.isci.2021.103048en_US
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofiScienceen_US
dc.rights© 2021 The Authors.en_US
dc.subjectMicrobiomeen_US
dc.subjectNeuroscienceen_US
dc.subjectNutritionen_US
dc.titlePost-weaning A1/A2 β-casein milk intake modulates depressive-like behavior, brain μ-opioid receptors, and the metabolome of ratsen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.isci.2021.103048
dc.identifier.pmid34585111
dc.source.volume24
dc.source.issue9
dc.source.beginpage103048
dc.source.endpage
dc.source.countryUnited States


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record