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dc.contributor.authorSoares, Cullen
dc.contributor.authorSamara, Amjad
dc.contributor.authorYuyun, Matthew F
dc.contributor.authorEchouffo-Tcheugui, Justin B
dc.contributor.authorMasri, Ahmad
dc.contributor.authorSamara, Ahmad
dc.contributor.authorMorrison, Alan R
dc.contributor.authorLin, Nina
dc.contributor.authorWu, Wen-Chih
dc.contributor.authorErqou, Sebhat
dc.date.accessioned2021-10-01T15:46:14Z
dc.date.available2021-10-01T15:46:14Z
dc.date.issued2021-09-29
dc.identifier.urihttp://hdl.handle.net/10713/16761
dc.description.abstractBackground Studies have reported that people living with HIV have higher burden of subclinical cardiovascular disease, but the data are not adequately synthesized. We performed meta-analyses of studies of coronary artery calcium and coronary plaque in people living with HIV. Methods and Results We performed systematic search in electronic databases, and data were abstracted in standardized forms. Study-specific estimates were pooled using meta-analysis. 43 reports representing 27 unique studies and involving 10 867 participants (6699 HIV positive, 4168 HIV negative, mean age 52 years, 86% men, 32% Black) were included. The HIV-positive participants were younger (mean age 49 versus 57 years) and had lower Framingham Risk Score (mean score 6 versus 18) compared with the HIV-negative participants. The pooled estimate of percentage with coronary artery calcium >0 was 45% (95% CI, 43%-47%) for HIV-positive participants, and 52% (50%-53%) for HIV-negative participants. This difference was no longer significant after adjusting for difference in Framingham Risk Score between the 2 groups. The odds ratio of coronary artery calcium progression for HIV-positive versus -negative participants was 1.64 (95% CI, 0.91-2.37). The pooled estimate for prevalence of noncalcified plaque was 49% (95% CI, 47%-52%) versus 20% (95% CI, 17%-23%) for HIV-positive versus HIV-negative participants, respectively. Odds ratio for noncalcified plaque for HIV-positive versus -negative participants was 1.23 (95% CI, 1.08-1.38). There was significant heterogeneity that was only partially explained by available study-level characteristics. Conclusions People living with HIV have higher prevalence of noncalcified coronary plaques and similar prevalence of coronary artery calcium, compared with HIV-negative individuals. Future studies on coronary artery calcium and plaque progression can further elucidate subclinical atherosclerosis in people living with HIV.en_US
dc.description.urihttps://doi.org/10.1161/JAHA.120.019291en_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofJournal of the American Heart Associationen_US
dc.subjectcalcium scoreen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectcoronary artery calciumen_US
dc.subjectcoronary plaqueen_US
dc.subjecthuman immunodeficiency virusen_US
dc.subjectsubclinical atherosclerosisen_US
dc.titleCoronary Artery Calcification and Plaque Characteristics in People Living With HIV: A Systematic Review and Meta-Analysisen_US
dc.typeArticleen_US
dc.identifier.doi10.1161/JAHA.120.019291
dc.identifier.pmid34585590
dc.source.beginpagee019291
dc.source.endpage
dc.source.countryEngland


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