• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Duration of SARS-CoV-2 sero-positivity in a large longitudinal sero-surveillance cohort: the COVID-19 Community Research Partnership

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Herrington, David M.
    Sanders, John W.
    Wierzba, Thomas F.
    Alexander-Miller, Martha
    Espeland, Mark
    Bertoni, Alain G.
    Mathews, Allison
    Seals, Austin L.
    Munawar, Iqra
    Runyon, Michael S.
    McCurdy, Lewis H.
    Gibbs, Michael A.
    Kotloff, Karen
    Friedman-Klabanoff, De Anna
    Weintraub, William
    Correa, Adolfo
    Uschner, Diane
    Edelstein, Sharon
    Santacatterina, Michele
    Show allShow less

    Date
    2021-08-30
    Journal
    BMC Infectious Diseases
    Publisher
    BMJ Publishing Group
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1186/s12879-021-06517-6
    Abstract
    Background: Estimating population prevalence and incidence of prior SARS-CoV-2 infection is essential to formulate public health recommendations concerning the COVID-19 pandemic. However, interpreting estimates based on sero-surveillance requires an understanding of the duration of elevated antibodies following SARS-CoV-2 infection, especially in the large number of people with pauci-symptomatic or asymptomatic disease. Methods: We examined > 30,000 serology assays for SARS-CoV-2 specific IgG and IgM assays acquired longitudinally in 11,468 adults between April and November 2020 in the COVID-19 Community Research Partnership. Results: Among participants with serologic evidence for infection but few or no symptoms or clinical disease, roughly 50% sero-reverted in 30 days of their initial positive test. Sero-reversion occurred more quickly for IgM than IgG and for antibodies targeting nucleocapsid protein compared with spike proteins, but was not associated with age, sex, race/ethnicity, or healthcare worker status. Conclusions: The short duration of antibody response suggests that the true population prevalence of prior SARS-CoV-2 infection may be significantly higher than presumed based on earlier sero-surveillance studies. The impact of the large number of minimally symptomatic COVID-19 cases with only a brief antibody response on population immunity remains to be determined.
    Sponsors
    U.S. Department of Health and Human Services
    Keyword
    COVID-19
    Humoral response
    Sero-surveillance
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/16744
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12879-021-06517-6
    Scopus Count
    Collections
    UMB Coronavirus Publications
    UMB Open Access Articles

    entitlement

    Related articles

    • [Seroprevalence of anti-SARS-CoV-2 IgG/IgM antibodies in Borgosesia (Piedmont Region, Northern Italy) population: a surveillance strategy in post-lockdown period?]
    • Authors: Alessi D, Borré S, Barale A, Isabella A, Milano F, Rossi MA, Silano V, Piu N, Cena T, Faggiano F, Gruppo di Lavoro Fondazione Valsesia.
    • Issue date: 2020 Sep-Dec
    • From first to second wave: follow-up of the prospective COVID-19 cohort (KoCo19) in Munich (Germany).
    • Authors: Radon K, Bakuli A, Pütz P, Le Gleut R, Guggenbuehl Noller JM, Olbrich L, Saathoff E, Garí M, Schälte Y, Frahnow T, Wölfel R, Pritsch M, Rothe C, Pletschette M, Rubio-Acero R, Beyerl J, Metaxa D, Forster F, Thiel V, Castelletti N, Rieß F, Diefenbach MN, Fröschl G, Bruger J, Winter S, Frese J, Puchinger K, Brand I, Kroidl I, Wieser A, Hoelscher M, Hasenauer J, Fuchs C, KoCo19 study group.
    • Issue date: 2021 Sep 8
    • From Multiplex Serology to Serolomics-A Novel Approach to the Antibody Response against the SARS-CoV-2 Proteome.
    • Authors: Butt J, Murugan R, Hippchen T, Olberg S, van Straaten M, Wardemann H, Stebbins E, Kräusslich HG, Bartenschlager R, Brenner H, Laketa V, Schöttker B, Müller B, Merle U, Waterboer T
    • Issue date: 2021 Apr 24
    • Enhanced surveillance of COVID-19 in Scotland: population-based seroprevalence surveillance for SARS-CoV-2 during the first wave of the epidemic.
    • Authors: Dickson E, Palmateer NE, Murray J, Robertson C, Waugh C, Wallace LA, Mathie L, Heatlie K, Mavin S, Gousias P, Von Wissman B, Goldberg DJ, McAuley A
    • Issue date: 2021 Jan
    • IgG and IgM antibody formation to spike and nucleocapsid proteins in COVID-19 characterized by multiplex immunoblot assays.
    • Authors: Shah J, Liu S, Potula HH, Bhargava P, Cruz I, Force D, Bazerbashi A, Ramasamy R
    • Issue date: 2021 Apr 7
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.