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    Association of acute psychosocial stress with oxidative stress: Evidence from serum analysis

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    Author
    Kim, Eunkyoung
    Zhao, Zhiling
    Rzasa, John Robertson
    Glassman, Matthew
    Bentley, William E
    Chen, Shuo
    Kelly, Deanna L
    Payne, Gregory F
    Date
    2021-09-16
    Journal
    Redox Biology
    Publisher
    Elsevier Inc.
    Type
    Article
    
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    https://doi.org/10.1016/j.redox.2021.102138
    Abstract
    Growing evidence implicates an association between psychosocial stress and oxidative stress (OxSt) although there are not yet reliable biomarkers to study this association. We used a Trier Social Stress Test (TSST) and compared the response of a healthy control group (HC; N=10) against the response of a schizophrenia group (SCZ; N=10) that is expected to have higher levels of OxSt. Because our previous study showed inconsistent changes in conventional molecular markers for stress responses in the neuroendocrine and immune systems, we analyzed the same serum samples using a separate reducing capacity assay that provides a more global measurement of OxSt. This assay uses the moderately strong oxidizing agent iridium (Ir) to probe a sample's reducing capacity. Specifically, we characterized OxSt by this Ir-reducing capacity assay (Ir-RCA) using two measurement modalities (optical and electrochemical) and we tuned this assay by imposing an input voltage sequence that generates multiple output metrics for data-driven analysis. We defined five OxSt metrics (one optical and four electrochemical metrics) and showed: (i) internal consistency among each metric in the measurements of all 40 samples (baseline and post TSST for N=20); (ii) all five metrics were consistent with expectations of higher levels of OxSt for the SCZ group (three individual metrics showed statistically significant differences); and (iii) all five metrics showed higher levels of OxSt Post-TSST (one metric showed statistically significant difference). Using multivariant analysis, we showed that combinations of OxSt metrics could discern statistically significant increases in OxSt for both the SCZ and HC groups 90 min after the imposed acute psychosocial stress.
    Rights/Terms
    Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
    Keyword
    Electrochemistry
    Oxidative stress
    Psychosocial stress
    Receiver operating characteristic (ROC)
    Schizophrenia
    Trier social stress test (TSST)
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/16726
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.redox.2021.102138
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