• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Short-term facilitation of breathing upon cessation of hypoxic challenge is impaired in male but not female endothelial NOS knock-out mice.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Getsy, Paulina M
    Sundararajan, Sripriya
    May, Walter J
    von Schill, Graham C
    McLaughlin, Dylan K
    Palmer, Lisa A
    Lewis, Stephen J
    Date
    2021-09-15
    Journal
    Scientific Reports
    Publisher
    Springer Nature
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1038/s41598-021-97322-3
    Abstract
    Decreases in arterial blood oxygen stimulate increases in minute ventilation via activation of peripheral and central respiratory structures. This study evaluates the role of endothelial nitric oxide synthase (eNOS) in the expression of the ventilatory responses during and following a hypoxic gas challenge (HXC, 10% O2, 90% N2) in freely moving male and female wild-type (WT) C57BL6 and eNOS knock-out (eNOS-/-) mice. Exposure to HXC caused an array of responses (of similar magnitude and duration) in both male and female WT mice such as, rapid increases in frequency of breathing, tidal volume, minute ventilation and peak inspiratory and expiratory flows, that were subject to pronounced roll-off. The responses to HXC in male eNOS-/- mice were similar to male WT mice. In contrast, several of the ventilatory responses in female eNOS-/- mice (e.g., frequency of breathing, and expiratory drive) were greater compared to female WT mice. Upon return to room-air, male and female WT mice showed similar excitatory ventilatory responses (i.e., short-term potentiation phase). These responses were markedly reduced in male eNOS-/- mice, whereas female eNOS-/- mice displayed robust post-HXC responses that were similar to those in female WT mice. Our data demonstrates that eNOS plays important roles in (1) ventilatory responses to HXC in female compared to male C57BL6 mice; and (2) expression of post-HXC responses in male, but not female C57BL6 mice. These data support existing evidence that sex, and the functional roles of specific proteins (e.g., eNOS) have profound influences on ventilatory processes, including the responses to HXC.
    Rights/Terms
    © 2021. The Author(s).
    Keyword
    arterial blood oxygen
    hypoxic gas challenge
    ventilatory processes
    Nitric Oxide Synthase Type III
    Sex Factors
    Mice
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/16688
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41598-021-97322-3
    Scopus Count
    Collections
    UMB Open Access Articles

    entitlement

    Related articles

    • Ventilatory responses during and following hypercapnic gas challenge are impaired in male but not female endothelial NOS knock-out mice.
    • Authors: Getsy PM, Sundararajan S, May WJ, von Schill GC, McLaughlin DK, Palmer LA, Lewis SJ
    • Issue date: 2021 Oct 18
    • Carotid sinus nerve transection abolishes the facilitation of breathing that occurs upon cessation of a hypercapnic gas challenge in male mice.
    • Authors: Getsy PM, Sundararajan S, Lewis SJ
    • Issue date: 2021 Aug 1
    • Hypoxia-induced ventilatory responses in conscious mice: gender differences in ventilatory roll-off and facilitation.
    • Authors: Palmer LA, May WJ, deRonde K, Brown-Steinke K, Gaston B, Lewis SJ
    • Issue date: 2013 Feb 1
    • Loss of Cervical Sympathetic Chain Input to the Superior Cervical Ganglia Affects the Ventilatory Responses to Hypoxic Challenge in Freely-Moving C57BL6 Mice.
    • Authors: Getsy PM, Coffee GA, Hsieh YH, Lewis SJ
    • Issue date: 2021
    • The superior cervical ganglia modulate ventilatory responses to hypoxia independently of preganglionic drive from the cervical sympathetic chain.
    • Authors: Getsy PM, Coffee GA, Hsieh YH, Lewis SJ
    • Issue date: 2021 Aug 1
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.