Date
2021-08-27Journal
FEBS journalPublisher
Wiley-BlackwellType
Article
Metadata
Show full item recordAbstract
Maternal obesity (MO) and gestational diabetes mellitus (GDM) are common in Western societies, which impair fetal development and predispose offspring to metabolic dysfunction. Placenta is the organ linking the mother to her fetus, and MO suppresses the development of vascular system and expression of nutrient transporters in placenta, thereby affecting fetal development. For maintaining its proper physiological function, placenta is energy demanding, which is met through extensive oxidative phosphorylation. However, the oxidative capacity of placenta is suppressed due to MO and GDM. Recently, several studies showed that physical activity during pregnancy enhances oxidative metabolism and improves placental function, which might be partially mediated by exerkines, referring to cytokines elicited by exercise. In addition, as an endocrine organ, placenta secretes cytokines, termed placentokines, including apelin, superoxide dismutase 3, irisin, and adiponectin, which mediate fetal development and maternal metabolism. Possible molecular mechanisms linking maternal exercise and placentokines to placental and fetal development are further discussed. As an emerging field, up to now, available studies are limited, mostly conducted in rodents. Given the epidemics of obesity and metabolic disorders, as well as the prevalence of maternal sedentary lifestyle, the effects of exercise of pregnant women on placental function and placentokine secretion, as well as their impacts on fetal development, need to be further examined. © 2021 Federation of European Biochemical SocietiesRights/Terms
© 2021 Federation of European Biochemical Societies.Identifier to cite or link to this item
http://hdl.handle.net/10713/16670ae974a485f413a2113503eed53cd6c53
10.1111/febs.16173
Scopus Count
Collections
Related articles
- Exerkine apelin reverses obesity-associated placental dysfunction by accelerating mitochondrial biogenesis in mice.
- Authors: Chae SA, Son JS, Zhao L, Gao Y, Liu X, Marie de Avila J, Zhu MJ, Du M
- Issue date: 2022 Jun 1
- Exercise prevents the adverse effects of maternal obesity on placental vascularization and fetal growth.
- Authors: Son JS, Liu X, Tian Q, Zhao L, Chen Y, Hu Y, Chae SA, de Avila JM, Zhu MJ, Du M
- Issue date: 2019 Jul
- Cinnamaldehyde mitigates placental vascular dysfunction of gestational diabetes and protects from the associated fetal hypoxia by modulating placental angiogenesis, metabolic activity and oxidative stress.
- Authors: Hosni A, El-Twab SA, Abdul-Hamid M, Prinsen E, AbdElgawad H, Abdel-Moneim A, Beemster GTS
- Issue date: 2021 Mar
- Role of omega-3 polyunsaturated fatty acids in gestational diabetes, maternal and fetal insights: current use and future directions.
- Authors: Elshani B, Kotori V, Daci A
- Issue date: 2021 Jan
- Maternal exercise alters rat fetoplacental stress response: Minimal effects of maternal growth restriction and high-fat feeding.
- Authors: Mangwiro YT, Cuffe JS, Vickers MH, Reynolds CM, Mahizir D, Anevska K, Gravina S, Romano T, Moritz KM, Briffa JF, Wlodek ME
- Issue date: 2021 Jan 15