• Login
    View Item 
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Determinants of Intrathoracic Adipose Tissue Volume and its Association with Cardiovascular Disease Risk Factors

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Liu_umaryland_0373D_10291.pdf
    Size:
    2.102Mb
    Format:
    PDF
    Download
    Author
    Liu, Xinggang
    Advisor
    Mitchell, Braxton D.
    Date
    2012
    Type
    dissertation
    
    Metadata
    Show full item record
    Abstract
    Background: The volume of intrathoracic fat has been associated in some studies with cardiovascular diseases risk factors. To further assess the role of intrathoracic fat in coronary atherosclerosis risk, we measured the volume of intrathoracic fat in 910 relatively healthy Amish adults from Lancaster County, PA, and assessed correlations of intrathoracic fat volume and its two subcomponents with cardiovascular risk factors and coronary artery calcification (CAC). Further we also explored the heritability and genetic determinants of intrathoracic fat volume. Methods and results: Intrathoracic fat, epicardial and pericardial fat volume were measured from EBCT scans (3-mm thickness) obtained from the right pulmonary artery to the diaphragm. There was high correlation between epicardial, pericardial and intrathoracic fat volume. Similar findings were observed while examine intrathoracic, epicardial and pericardial fat volume. Epicardial fat volume was significantly correlated with older age (p<0.001), male gender (p<0.01), and increasing BMI (p<0.001). Multivariate regression model was used to evaluate the correlation between epicardial fat volume and cardiovascular disease risk factors while adjusting for age, gender, family structure and BMI. Epicardial fat volume was associated with higher systolic (p<0.01) and diastolic (p=0.04) blood pressure, higher pulse pressure (p=0.02), higher levels of fasting glucose, insulin, triglycerides (p<0.001) and total cholesterol (p=0.05). After adjusting for BMI or waist circumference, the above associations were diminished and no longer statistically significant. Neither coronary calcification score nor coronary calcification presence (coronary calcification score>0) was associated with increased epicardial fat volume after adjusting for age and gender. Similar associations were found examining pericardial and intrathoracic fat volume. Genetic analysis revealed that intrathoracic fat shares both environmental and genetic determinants with other obesity traits. Our genome wide association analysis and targeted SNPs analysis identified several candidate SNPs/genes which might be specifically associated with this regional fat deposit. Conclusions: We conclude that intrathoracic fat volume is significantly correlated with adverse cardiovascular risk factors (although not with increased CAC) in age and gender adjusted models. However, the associations were not independent of BMI. Intrathoracic fat volume closely correlates with various obesity measurements, except liver fat, by sharing both similar environmental and genetic influences.
    Description
    University of Maryland, Baltimore. Epidemiology and Preventive Medicine. Ph.D. 2012
    Keyword
    intrathoracic adipose tissue
    Cardiovascular Diseases
    Genome-Wide Association Study
    Obesity
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/1666
    Collections
    Theses and Dissertations All Schools
    Theses and Dissertations School of Medicine

    entitlement

     
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.