Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response
AuthorRickard, Brittany P
Sorrin, Aaron J
Ruhi, Mustafa Kemal
Reader, Jocelyn C
Huang, Stephanie A
Polacheck, William J
Roque, Dana M
Del Carmen, Marcela G
MetadataShow full item record
AbstractAscites refers to the abnormal accumulation of fluid in the peritoneum resulting from an underlying pathology, such as metastatic cancer. Among all cancers, advanced-stage epithelial ovarian cancer is most frequently associated with the production of malignant ascites and is the leading cause of death from gynecologic malignancies. Despite decades of evidence showing that the accumulation of peritoneal fluid portends the poorest outcomes for cancer patients, the role of malignant ascites in promoting metastasis and therapy resistance remains poorly understood. This review summarizes the current understanding of malignant ascites, with a focus on ovarian cancer. The first section provides an overview of heterogeneity in ovarian cancer and the pathophysiology of malignant ascites. Next, analytical methods used to characterize the cellular and acellular components of malignant ascites, as well the role of these components in modulating cell biology, are discussed. The review then provides a perspective on the pressures and forces that tumors are subjected to in the presence of malignant ascites and the impact of physical stress on therapy resistance. Treatment options for malignant ascites, including surgical, pharmacological and photochemical interventions are then discussed to highlight challenges and opportunities at the interface of drug discovery, device development and physical sciences in oncology. © 2021 by the authors.
epithelial ovarian cancer
epithelial to mesenchymal transition
flow-induced shear stress
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/16645
- Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules.
- Authors: Rizvi I, Gurkan UA, Tasoglu S, Alagic N, Celli JP, Mensah LB, Mai Z, Demirci U, Hasan T
- Issue date: 2013 May 28
- Flow-induced Shear Stress Confers Resistance to Carboplatin in an Adherent Three-Dimensional Model for Ovarian Cancer: A Role for EGFR-Targeted Photoimmunotherapy Informed by Physical Stress.
- Authors: Nath S, Pigula M, Khan AP, Hanna W, Ruhi MK, Dehkordy FM, Pushpavanam K, Rege K, Moore K, Tsujita Y, Conrad C, Inci F, Carmen MGD, Franco W, Celli JP, Demirci U, Hasan T, Huang HC, Rizvi I
- Issue date: 2020 Mar 28
- Getting to know ovarian cancer ascites: opportunities for targeted therapy-based translational research.
- Authors: Ahmed N, Stenvers KL
- Issue date: 2013 Sep 25
- Ascites modulates cancer cell behavior, contributing to tumor heterogeneity in ovarian cancer.
- Authors: Kim S, Kim B, Song YS
- Issue date: 2016 Sep
- Ubiquitin-Proteasome Axis, Especially Ubiquitin-Specific Protease-17 (<i>USP17</i>) Gene Family, is a Potential Target for Epithelial-Mesenchymal Transition in High-Grade Serous Ovarian Cancer.
- Authors: Yildirim N, Kocal GC, Isik Z, Saatli B, Saygili U, Uysal T, Ulukus C, Koyuncuoglu M, Ellidokuz H, Basbinar Y
- Issue date: 2019 Jun