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dc.contributor.authorBotti-Lodovico, Yolanda
dc.contributor.authorNair, Parvathy
dc.contributor.authorNosamiefan, Dolo
dc.contributor.authorStremlau, Matthew
dc.contributor.authorSchaffner, Stephen
dc.contributor.authorAgignoae, Sebastian V
dc.contributor.authorAiyepada, John Oke
dc.contributor.authorAjogbasile, Fehintola V
dc.contributor.authorAkpede, George O
dc.contributor.authorAlhasan, Foday
dc.contributor.authorAndersen, Kristian G
dc.contributor.authorAsogun, Danny A
dc.contributor.authorAyodeji, Oladele Oluwafemi
dc.contributor.authorBadiane, Aida S
dc.contributor.authorBarnes, Kayla
dc.contributor.authorBauer, Matthew R
dc.contributor.authorBell-Kareem, Antoinette
dc.contributor.authorBenard, Muoebonam Ekene
dc.contributor.authorBenevolence, Ebo Ohomoime
dc.contributor.authorBlessing, Osiemi
dc.contributor.authorBoehm, Chloe K
dc.contributor.authorBoisen, Matthew L
dc.contributor.authorBond, Nell G
dc.contributor.authorBranco, Luis M
dc.contributor.authorButts, Michael J
dc.contributor.authorCarter, Amber
dc.contributor.authorColubri, Andres
dc.contributor.authorDeme, Awa B
dc.contributor.authorDeRuff, Katherine C
dc.contributor.authorDiédhiou, Younousse
dc.contributor.authorEdamhande, Akhilomen Patience
dc.contributor.authorElhamoumi, Siham
dc.contributor.authorEngel, Emily J
dc.contributor.authorEromon, Philomena
dc.contributor.authorFallah, Mosoka
dc.contributor.authorFolarin, Onikepe A
dc.contributor.authorFry, Ben
dc.contributor.authorGarry, Robert
dc.contributor.authorGaye, Amy
dc.contributor.authorGbakie, Michael
dc.contributor.authorGevao, Sahr M
dc.contributor.authorGionet, Gabrielle
dc.contributor.authorGladden-Young, Adrianne
dc.contributor.authorGoba, Augustine
dc.contributor.authorGomis, Jules Francois
dc.contributor.authorHappi, Anise N
dc.contributor.authorHoughton, Mary
dc.contributor.authorIhekwuazu, Chikwe
dc.contributor.authorIruolagbe, Christopher Ojemiega
dc.contributor.authorJackson, Jonathan
dc.contributor.authorJalloh, Simbirie
dc.contributor.authorJohnson, Jeremy
dc.contributor.authorKanneh, Lansana
dc.contributor.authorKayode, Adeyemi
dc.contributor.authorKemball, Molly
dc.contributor.authorKingsley, Ojide Chiedozie
dc.contributor.authorKoroma, Veronica
dc.contributor.authorKotliar, Dylan
dc.contributor.authorMehta, Samar
dc.contributor.authorMetsky, Hayden C
dc.contributor.authorMichael, Airende
dc.contributor.authorMirhashemi, Marzieh Ezzaty
dc.contributor.authorModjarrad, Kayvon
dc.contributor.authorMomoh, Mambu
dc.contributor.authorMyhrvold, Cameron A
dc.contributor.authorNaregose, Okonofua Grace
dc.contributor.authorNdiaye, Tolla
dc.contributor.authorNdiaye, Mouhamadou
dc.contributor.authorNdiaye, Aliou
dc.contributor.authorNormandin, Erica
dc.contributor.authorOdia, Ikponmwosa
dc.contributor.authorOguzie, Judith Uche
dc.contributor.authorOkogbenin, Sylvanus A
dc.contributor.authorOkokhere, Peter O
dc.contributor.authorOkolie, Johnson
dc.contributor.authorOlawoye, Idowu B
dc.contributor.authorOlumade, Testimony J
dc.contributor.authorOluniyi, Paul E
dc.contributor.authorOmoregie, Omigie
dc.contributor.authorPark, Daniel J
dc.contributor.authorPaye, Mariétou Faye
dc.contributor.authorPetros, Brittany
dc.contributor.authorPhilippakis, Anthony A
dc.contributor.authorPriscilla, Abechi
dc.contributor.authorRicks, Alan
dc.contributor.authorRimoin, Anne
dc.contributor.authorSandi, John Demby
dc.contributor.authorSchieffelin, John S
dc.contributor.authorSchreiber, Monica
dc.contributor.authorSeck, Mame Cheikh
dc.contributor.authorSiddiqui, Sameed
dc.contributor.authorSiddle, Katherine
dc.contributor.authorSmither, Allison R
dc.contributor.authorSy, Mouhamad
dc.contributor.authorSy, Ngayo
dc.contributor.authorTomkins-Tinch, Christopher H
dc.contributor.authorTomori, Oyewale
dc.contributor.authorUgwu, Chinedu
dc.contributor.authorUwanibe, Jessica N
dc.contributor.authorUyigue, Eghosasere Anthonia
dc.contributor.authorVictoria, Dada Ireti
dc.contributor.authorVinzé, Anika
dc.contributor.authorVodzak, Megan E
dc.contributor.authorWelch, Nicole
dc.contributor.authorWurie, Haja Isatta
dc.contributor.authorZoumarou, Daba
dc.contributor.authorGrant, Donald S
dc.contributor.authorNdiaye, Daouda
dc.contributor.authorMacInnis, Bronwyn
dc.contributor.authorSabeti, Pardis C
dc.contributor.authorHappi, Christian
dc.date.accessioned2021-09-14T14:08:21Z
dc.date.available2021-09-14T14:08:21Z
dc.date.issued2021-08-13
dc.identifier.urihttp://hdl.handle.net/10713/16633
dc.description.abstractWhile investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work to test our hypothesis that natural selection acting on LARGE—detected in the Yoruba population of Nigeria—conferred resistance to Lassa Fever in some West African populations. As we delved further, we conjectured that the “emerging” nature of recently discovered diseases like Lassa fever is related to a newfound capacity for detection, rather than a novel viral presence, and that humans have in fact been exposed to the viruses that cause such diseases for much longer than previously suspected. Dr. Stefan Kunz’s critical efforts not only laid the groundwork for this discovery, but also inspired and catalyzed a series of events that birthed Sentinel, an ambitious and large-scale pandemic prevention effort in West Africa. Sentinel aims to detect and characterize deadly pathogens before they spread across the globe, through implementation of its three fundamental pillars: Detect, Connect, and Empower. More specifically, Sentinel is designed to detect known and novel infections rapidly, connect and share information in real time to identify emerging threats, and empower the public health community to improve pandemic preparedness and response anywhere in the world. We are proud to dedicate this work to Stefan Kunz, and eagerly invite new collaborators, experts, and others to join us in our efforts. © 2021 by the authors.en_US
dc.description.urihttps://doi.org/10.3390/v13081605en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofVirusesen_US
dc.subjectEbolaen_US
dc.subjectLARGEen_US
dc.subjectLassa feveren_US
dc.subjectLassa virusen_US
dc.subjectbioinformaticsen_US
dc.subjectdiagnostic toolsen_US
dc.subjectgenomic surveillanceen_US
dc.subjectinfectious diseaseen_US
dc.subjectpandemic preemptionen_US
dc.subjectpandemic responseen_US
dc.titleThe Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Responseen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/v13081605
dc.identifier.pmid34452470
dc.source.volume13
dc.source.issue8
dc.source.countrySwitzerland


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