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    The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response

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    Author
    Botti-Lodovico, Yolanda
    Nair, Parvathy
    Nosamiefan, Dolo
    Stremlau, Matthew
    Schaffner, Stephen
    Agignoae, Sebastian V
    Aiyepada, John Oke
    Ajogbasile, Fehintola V
    Akpede, George O
    Alhasan, Foday
    Andersen, Kristian G
    Asogun, Danny A
    Ayodeji, Oladele Oluwafemi
    Badiane, Aida S
    Barnes, Kayla
    Bauer, Matthew R
    Bell-Kareem, Antoinette
    Benard, Muoebonam Ekene
    Benevolence, Ebo Ohomoime
    Blessing, Osiemi
    Boehm, Chloe K
    Boisen, Matthew L
    Bond, Nell G
    Branco, Luis M
    Butts, Michael J
    Carter, Amber
    Colubri, Andres
    Deme, Awa B
    DeRuff, Katherine C
    Diédhiou, Younousse
    Edamhande, Akhilomen Patience
    Elhamoumi, Siham
    Engel, Emily J
    Eromon, Philomena
    Fallah, Mosoka
    Folarin, Onikepe A
    Fry, Ben
    Garry, Robert
    Gaye, Amy
    Gbakie, Michael
    Gevao, Sahr M
    Gionet, Gabrielle
    Gladden-Young, Adrianne
    Goba, Augustine
    Gomis, Jules Francois
    Happi, Anise N
    Houghton, Mary
    Ihekwuazu, Chikwe
    Iruolagbe, Christopher Ojemiega
    Jackson, Jonathan
    Jalloh, Simbirie
    Johnson, Jeremy
    Kanneh, Lansana
    Kayode, Adeyemi
    Kemball, Molly
    Kingsley, Ojide Chiedozie
    Koroma, Veronica
    Kotliar, Dylan
    Mehta, Samar
    Metsky, Hayden C
    Michael, Airende
    Mirhashemi, Marzieh Ezzaty
    Modjarrad, Kayvon
    Momoh, Mambu
    Myhrvold, Cameron A
    Naregose, Okonofua Grace
    Ndiaye, Tolla
    Ndiaye, Mouhamadou
    Ndiaye, Aliou
    Normandin, Erica
    Odia, Ikponmwosa
    Oguzie, Judith Uche
    Okogbenin, Sylvanus A
    Okokhere, Peter O
    Okolie, Johnson
    Olawoye, Idowu B
    Olumade, Testimony J
    Oluniyi, Paul E
    Omoregie, Omigie
    Park, Daniel J
    Paye, Mariétou Faye
    Petros, Brittany
    Philippakis, Anthony A
    Priscilla, Abechi
    Ricks, Alan
    Rimoin, Anne
    Sandi, John Demby
    Schieffelin, John S
    Schreiber, Monica
    Seck, Mame Cheikh
    Siddiqui, Sameed
    Siddle, Katherine
    Smither, Allison R
    Sy, Mouhamad
    Sy, Ngayo
    Tomkins-Tinch, Christopher H
    Tomori, Oyewale
    Ugwu, Chinedu
    Uwanibe, Jessica N
    Uyigue, Eghosasere Anthonia
    Victoria, Dada Ireti
    Vinzé, Anika
    Vodzak, Megan E
    Welch, Nicole
    Wurie, Haja Isatta
    Zoumarou, Daba
    Grant, Donald S
    Ndiaye, Daouda
    MacInnis, Bronwyn
    Sabeti, Pardis C
    Happi, Christian
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    Date
    2021-08-13
    Journal
    Viruses
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/v13081605
    Abstract
    While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work to test our hypothesis that natural selection acting on LARGE—detected in the Yoruba population of Nigeria—conferred resistance to Lassa Fever in some West African populations. As we delved further, we conjectured that the “emerging” nature of recently discovered diseases like Lassa fever is related to a newfound capacity for detection, rather than a novel viral presence, and that humans have in fact been exposed to the viruses that cause such diseases for much longer than previously suspected. Dr. Stefan Kunz’s critical efforts not only laid the groundwork for this discovery, but also inspired and catalyzed a series of events that birthed Sentinel, an ambitious and large-scale pandemic prevention effort in West Africa. Sentinel aims to detect and characterize deadly pathogens before they spread across the globe, through implementation of its three fundamental pillars: Detect, Connect, and Empower. More specifically, Sentinel is designed to detect known and novel infections rapidly, connect and share information in real time to identify emerging threats, and empower the public health community to improve pandemic preparedness and response anywhere in the world. We are proud to dedicate this work to Stefan Kunz, and eagerly invite new collaborators, experts, and others to join us in our efforts. © 2021 by the authors.
    Keyword
    Ebola
    LARGE
    Lassa fever
    Lassa virus
    bioinformatics
    diagnostic tools
    genomic surveillance
    infectious disease
    pandemic preemption
    pandemic response
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/16633
    ae974a485f413a2113503eed53cd6c53
    10.3390/v13081605
    Scopus Count
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