The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response
Author
Botti-Lodovico, YolandaNair, Parvathy
Nosamiefan, Dolo
Stremlau, Matthew
Schaffner, Stephen
Agignoae, Sebastian V
Aiyepada, John Oke
Ajogbasile, Fehintola V
Akpede, George O
Alhasan, Foday
Andersen, Kristian G
Asogun, Danny A
Ayodeji, Oladele Oluwafemi
Badiane, Aida S
Barnes, Kayla
Bauer, Matthew R
Bell-Kareem, Antoinette
Benard, Muoebonam Ekene
Benevolence, Ebo Ohomoime
Blessing, Osiemi
Boehm, Chloe K
Boisen, Matthew L
Bond, Nell G
Branco, Luis M
Butts, Michael J
Carter, Amber
Colubri, Andres
Deme, Awa B
DeRuff, Katherine C
Diédhiou, Younousse
Edamhande, Akhilomen Patience
Elhamoumi, Siham
Engel, Emily J
Eromon, Philomena
Fallah, Mosoka
Folarin, Onikepe A
Fry, Ben
Garry, Robert
Gaye, Amy
Gbakie, Michael
Gevao, Sahr M
Gionet, Gabrielle
Gladden-Young, Adrianne
Goba, Augustine
Gomis, Jules Francois
Happi, Anise N
Houghton, Mary
Ihekwuazu, Chikwe
Iruolagbe, Christopher Ojemiega
Jackson, Jonathan
Jalloh, Simbirie
Johnson, Jeremy
Kanneh, Lansana
Kayode, Adeyemi
Kemball, Molly
Kingsley, Ojide Chiedozie
Koroma, Veronica
Kotliar, Dylan
Mehta, Samar
Metsky, Hayden C
Michael, Airende
Mirhashemi, Marzieh Ezzaty
Modjarrad, Kayvon
Momoh, Mambu
Myhrvold, Cameron A
Naregose, Okonofua Grace
Ndiaye, Tolla
Ndiaye, Mouhamadou
Ndiaye, Aliou
Normandin, Erica
Odia, Ikponmwosa
Oguzie, Judith Uche
Okogbenin, Sylvanus A
Okokhere, Peter O
Okolie, Johnson
Olawoye, Idowu B
Olumade, Testimony J
Oluniyi, Paul E
Omoregie, Omigie
Park, Daniel J
Paye, Mariétou Faye
Petros, Brittany
Philippakis, Anthony A
Priscilla, Abechi
Ricks, Alan
Rimoin, Anne
Sandi, John Demby
Schieffelin, John S
Schreiber, Monica
Seck, Mame Cheikh
Siddiqui, Sameed
Siddle, Katherine
Smither, Allison R
Sy, Mouhamad
Sy, Ngayo
Tomkins-Tinch, Christopher H
Tomori, Oyewale
Ugwu, Chinedu
Uwanibe, Jessica N
Uyigue, Eghosasere Anthonia
Victoria, Dada Ireti
Vinzé, Anika
Vodzak, Megan E
Welch, Nicole
Wurie, Haja Isatta
Zoumarou, Daba
Grant, Donald S
Ndiaye, Daouda
MacInnis, Bronwyn
Sabeti, Pardis C
Happi, Christian
Date
2021-08-13Journal
VirusesPublisher
MDPI AGType
Article
Metadata
Show full item recordAbstract
While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work to test our hypothesis that natural selection acting on LARGE—detected in the Yoruba population of Nigeria—conferred resistance to Lassa Fever in some West African populations. As we delved further, we conjectured that the “emerging” nature of recently discovered diseases like Lassa fever is related to a newfound capacity for detection, rather than a novel viral presence, and that humans have in fact been exposed to the viruses that cause such diseases for much longer than previously suspected. Dr. Stefan Kunz’s critical efforts not only laid the groundwork for this discovery, but also inspired and catalyzed a series of events that birthed Sentinel, an ambitious and large-scale pandemic prevention effort in West Africa. Sentinel aims to detect and characterize deadly pathogens before they spread across the globe, through implementation of its three fundamental pillars: Detect, Connect, and Empower. More specifically, Sentinel is designed to detect known and novel infections rapidly, connect and share information in real time to identify emerging threats, and empower the public health community to improve pandemic preparedness and response anywhere in the world. We are proud to dedicate this work to Stefan Kunz, and eagerly invite new collaborators, experts, and others to join us in our efforts. © 2021 by the authors.Keyword
EbolaLARGE
Lassa fever
Lassa virus
bioinformatics
diagnostic tools
genomic surveillance
infectious disease
pandemic preemption
pandemic response
Identifier to cite or link to this item
http://hdl.handle.net/10713/16633ae974a485f413a2113503eed53cd6c53
10.3390/v13081605
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