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dc.contributor.authorKaur, Kawaljit
dc.contributor.authorVaziri, Shahram
dc.contributor.authorRomero-Reyes, Marcela
dc.contributor.authorParanjpe, Avina
dc.contributor.authorJewett, Anahid
dc.date.accessioned2021-09-14T13:46:20Z
dc.date.available2021-09-14T13:46:20Z
dc.date.issued2021-02-20
dc.identifier.urihttp://hdl.handle.net/10713/16629
dc.description.abstractSurvival and function of immune subsets in the oral blood, peripheral blood and gingival tissues of patients with periodontal disease and healthy controls were assessed. NK and CD8 + T cells within the oral blood mononuclear cells (OBMCs) expressed significantly higher levels of CD69 in patients with periodontal disease compared to those from healthy controls. Similarly, TNF-α release was higher from oral blood of patients with periodontal disease when compared to healthy controls. Increased activation induced cell death of peripheral blood mononuclear cells (PBMCs) but not OBMCs from patients with periodontal disease was observed when compared to those from healthy individuals. Unlike those from healthy individuals, OBMC-derived supernatants from periodontitis patients exhibited decreased ability to induce secretion of IFN-γ by allogeneic healthy PBMCs treated with IL-2, while they triggered significant levels of TNF-α, IL-1β and IL-6 by untreated PBMCs. Interaction of PBMCs, or NK cells with intact or NFκB knock down oral epithelial cells in the presence of a periodontal pathogen, F. nucleatum, significantly induced a number of pro-inflammatory cytokines including IFN-γ. These studies indicated that the relative numbers of immune subsets obtained from peripheral blood may not represent the composition of the immune cells in the oral environment, and that orally-derived immune effectors may differ in survival and function from those of peripheral blood.en_US
dc.description.urihttps://doi.org/10.3390/jcm10040875en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofJournal of Clinical Medicineen_US
dc.subjectCD69en_US
dc.subjectF. nucleatumen_US
dc.subjectIFN-γen_US
dc.subjectNFκBen_US
dc.subjectcell deathen_US
dc.subjectoral blooden_US
dc.subjectperiodontitisen_US
dc.titlePhenotypic and Functional Alterations of Immune Effectors in Periodontitis; A Multifactorial and Complex Oral Diseaseen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/jcm10040875
dc.identifier.pmid33672708
dc.source.volume10
dc.source.issue4
dc.source.countryUnited States
dc.source.countrySwitzerland


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