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dc.contributor.authorGutman, Boris A
dc.contributor.authorvan Erp, Theo G M
dc.contributor.authorAlpert, Kathryn
dc.contributor.authorChing, Christopher R K
dc.contributor.authorIsaev, Dmitry
dc.contributor.authorRagothaman, Anjani
dc.contributor.authorJahanshad, Neda
dc.contributor.authorSaremi, Arvin
dc.contributor.authorZavaliangos-Petropulu, Artemis
dc.contributor.authorGlahn, David C
dc.contributor.authorShen, Li
dc.contributor.authorCong, Shan
dc.contributor.authorAlnaes, Dag
dc.contributor.authorAndreassen, Ole Andreas
dc.contributor.authorDoan, Nhat Trung
dc.contributor.authorWestlye, Lars T
dc.contributor.authorKochunov, Peter
dc.contributor.authorSatterthwaite, Theodore D
dc.contributor.authorWolf, Daniel H
dc.contributor.authorHuang, Alexander J
dc.contributor.authorKessler, Charles
dc.contributor.authorWeideman, Andrea
dc.contributor.authorNguyen, Dana
dc.contributor.authorMueller, Bryon A
dc.contributor.authorFaziola, Lawrence
dc.contributor.authorPotkin, Steven G
dc.contributor.authorPreda, Adrian
dc.contributor.authorMathalon, Daniel H
dc.contributor.authorBustillo, Juan
dc.contributor.authorCalhoun, Vince
dc.contributor.authorFord, Judith M
dc.contributor.authorWalton, Esther
dc.contributor.authorEhrlich, Stefan
dc.contributor.authorDucci, Giuseppe
dc.contributor.authorBanaj, Nerisa
dc.contributor.authorPiras, Fabrizio
dc.contributor.authorPiras, Federica
dc.contributor.authorSpalletta, Gianfranco
dc.contributor.authorCanales-Rodríguez, Erick J
dc.contributor.authorFuentes-Claramonte, Paola
dc.contributor.authorPomarol-Clotet, Edith
dc.contributor.authorRadua, Joaquim
dc.contributor.authorSalvador, Raymond
dc.contributor.authorSarró, Salvador
dc.contributor.authorDickie, Erin W
dc.contributor.authorVoineskos, Aristotle
dc.contributor.authorTordesillas-Gutiérrez, Diana
dc.contributor.authorCrespo-Facorro, Benedicto
dc.contributor.authorSetién-Suero, Esther
dc.contributor.authorvan Son, Jacqueline Mayoral
dc.contributor.authorBorgwardt, Stefan
dc.contributor.authorSchönborn-Harrisberger, Fabienne
dc.contributor.authorMorris, Derek
dc.contributor.authorDonohoe, Gary
dc.contributor.authorHolleran, Laurena
dc.contributor.authorCannon, Dara
dc.contributor.authorMcDonald, Colm
dc.contributor.authorCorvin, Aiden
dc.contributor.authorGill, Michael
dc.contributor.authorFilho, Geraldo Busatto
dc.contributor.authorRosa, Pedro G P
dc.contributor.authorSerpa, Mauricio H
dc.contributor.authorZanetti, Marcus V
dc.contributor.authorLebedeva, Irina
dc.contributor.authorKaleda, Vasily
dc.contributor.authorTomyshev, Alexander
dc.contributor.authorCrow, Tim
dc.contributor.authorJames, Anthony
dc.contributor.authorCervenka, Simon
dc.contributor.authorSellgren, Carl M
dc.contributor.authorFatouros-Bergman, Helena
dc.contributor.authorAgartz, Ingrid
dc.contributor.authorHowells, Fleur
dc.contributor.authorStein, Dan J
dc.contributor.authorTemmingh, Henk
dc.contributor.authorUhlmann, Anne
dc.contributor.authorde Zubicaray, Greig I
dc.contributor.authorMcMahon, Katie L
dc.contributor.authorWright, Margie
dc.contributor.authorCobia, Derin
dc.contributor.authorCsernansky, John G
dc.contributor.authorThompson, Paul M
dc.contributor.authorTurner, Jessica A
dc.contributor.authorWang, Lei
dc.date.accessioned2021-09-14T13:07:33Z
dc.date.available2021-09-14T13:07:33Z
dc.date.issued2021-09-08
dc.identifier.urihttp://hdl.handle.net/10713/16627
dc.description.abstractSchizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta-analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences between individuals with schizophrenia and healthy control participants. The study analyzed data from 2,833 individuals with schizophrenia and 3,929 healthy control participants contributed by 21 worldwide research groups participating in the ENIGMA Schizophrenia Working Group. Harmonized shape analysis protocols were applied to each site's data independently for bilateral hippocampus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained from T1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens, and thalamus in individuals with schizophrenia compared with control participants, more-convex-than-concave shape differences in the putamen and pallidum, and both concave and convex shape differences in the caudate. Patterns of exaggerated asymmetry were observed across the hippocampus, amygdala, and thalamus in individuals with schizophrenia compared to control participants, while diminished asymmetry encompassed ventral striatum and ventral and dorsal thalamus. Our analyses also revealed that higher chlorpromazine dose equivalents and increased positive symptom levels were associated with patterns of contiguous convex shape differences across multiple subcortical structures. Findings from our shape meta-analysis suggest that common neurobiological mechanisms may contribute to gray matter reduction across multiple subcortical regions, thus enhancing our understanding of the nature of network disorganization in schizophrenia. © 2021 The Authors.en_US
dc.description.urihttps://doi.org/10.1002/hbm.25625en_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofHuman brain mappingen_US
dc.rights© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.en_US
dc.subjectschizophreniaen_US
dc.subjectstructureen_US
dc.subjectsubcortical shapeen_US
dc.titleA meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortiumen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/hbm.25625
dc.identifier.pmid34498337
dc.source.countryUnited States
dc.source.countryIreland
dc.source.countryIreland
dc.source.countryUnited Kingdom


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