Show simple item record

dc.contributor.authorLumbers, R Thomas
dc.contributor.authorShah, Sonia
dc.contributor.authorLin, Honghuang
dc.contributor.authorCzuba, Tomasz
dc.contributor.authorHenry, Albert
dc.contributor.authorSwerdlow, Daniel I
dc.contributor.authorMälarstig, Anders
dc.contributor.authorAndersson, Charlotte
dc.contributor.authorVerweij, Niek
dc.contributor.authorHolmes, Michael V
dc.contributor.authorÄrnlöv, Johan
dc.contributor.authorSvensson, Per
dc.contributor.authorHemingway, Harry
dc.contributor.authorSallah, Neneh
dc.contributor.authorAlmgren, Peter
dc.contributor.authorAragam, Krishna G
dc.contributor.authorAsselin, Geraldine
dc.contributor.authorBackman, Joshua D
dc.contributor.authorBiggs, Mary L
dc.contributor.authorBloom, Heather L
dc.contributor.authorBoersma, Eric
dc.contributor.authorBrandimarto, Jeffrey
dc.contributor.authorBrown, Michael R
dc.contributor.authorBrunner-La Rocca, Hans-Peter
dc.contributor.authorCarey, David J
dc.contributor.authorChaffin, Mark D
dc.contributor.authorChasman, Daniel I
dc.contributor.authorChazara, Olympe
dc.contributor.authorChen, Xing
dc.contributor.authorChen, Xu
dc.contributor.authorChung, Jonathan H
dc.contributor.authorChutkow, William
dc.contributor.authorCleland, John G F
dc.contributor.authorCook, James P
dc.contributor.authorde Denus, Simon
dc.contributor.authorDehghan, Abbas
dc.contributor.authorDelgado, Graciela E
dc.contributor.authorDenaxas, Spiros
dc.contributor.authorDoney, Alexander S
dc.contributor.authorDörr, Marcus
dc.contributor.authorDudley, Samuel C
dc.contributor.authorEngström, Gunnar
dc.contributor.authorEsko, Tõnu
dc.contributor.authorFatemifar, Ghazaleh
dc.contributor.authorFelix, Stephan B
dc.contributor.authorFinan, Chris
dc.contributor.authorFord, Ian
dc.contributor.authorFougerousse, Francoise
dc.contributor.authorFouodjio, René
dc.contributor.authorGhanbari, Mohsen
dc.contributor.authorGhasemi, Sahar
dc.contributor.authorGiedraitis, Vilmantas
dc.contributor.authorGiulianini, Franco
dc.contributor.authorGottdiener, John S
dc.contributor.authorGross, Stefan
dc.contributor.authorGuðbjartsson, Daníel F
dc.contributor.authorGui, Hongsheng
dc.contributor.authorGutmann, Rebecca
dc.contributor.authorHaggerty, Christopher M
dc.contributor.authorvan der Harst, Pim
dc.contributor.authorHedman, Åsa K
dc.contributor.authorHelgadottir, Anna
dc.contributor.authorHillege, Hans
dc.contributor.authorHyde, Craig L
dc.contributor.authorJacob, Jaison
dc.contributor.authorJukema, J Wouter
dc.contributor.authorKamanu, Frederick
dc.contributor.authorKardys, Isabella
dc.contributor.authorKavousi, Maryam
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorKleber, Marcus E
dc.contributor.authorKøber, Lars
dc.contributor.authorKoekemoer, Andrea
dc.contributor.authorKraus, Bill
dc.contributor.authorKuchenbaecker, Karoline
dc.contributor.authorLangenberg, Claudia
dc.contributor.authorLind, Lars
dc.contributor.authorLindgren, Cecilia M
dc.contributor.authorLondon, Barry
dc.contributor.authorLotta, Luca A
dc.contributor.authorLovering, Ruth C
dc.contributor.authorLuan, Jian'an
dc.contributor.authorMagnusson, Patrik
dc.contributor.authorMahajan, Anubha
dc.contributor.authorMann, Douglas
dc.contributor.authorMargulies, Kenneth B
dc.contributor.authorMarston, Nicholas A
dc.contributor.authorMärz, Winfried
dc.contributor.authorMcMurray, John J V
dc.contributor.authorMelander, Olle
dc.contributor.authorMelloni, Giorgio
dc.contributor.authorMordi, Ify R
dc.contributor.authorMorley, Michael P
dc.contributor.authorMorris, Andrew D
dc.contributor.authorMorris, Andrew P
dc.contributor.authorMorrison, Alanna C
dc.contributor.authorNagle, Michael W
dc.contributor.authorNelson, Christopher P
dc.contributor.authorNewton-Cheh, Christopher
dc.contributor.authorNiessner, Alexander
dc.contributor.authorNiiranen, Teemu
dc.contributor.authorNowak, Christoph
dc.contributor.authorO'Donoghue, Michelle L
dc.contributor.authorOwens, Anjali T
dc.contributor.authorPalmer, Colin N A
dc.contributor.authorParé, Guillaume
dc.contributor.authorPerola, Markus
dc.contributor.authorPerreault, Louis-Philippe Lemieux
dc.contributor.authorPortilla-Fernandez, Eliana
dc.contributor.authorPsaty, Bruce M
dc.contributor.authorRice, Kenneth M
dc.contributor.authorRidker, Paul M
dc.contributor.authorRomaine, Simon P R
dc.contributor.authorRoselli, Carolina
dc.contributor.authorRotter, Jerome I
dc.contributor.authorRuff, Christian T
dc.contributor.authorSabatine, Marc S
dc.contributor.authorSalo, Perttu
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorvan Setten, Jessica
dc.contributor.authorShalaby, Alaa A
dc.contributor.authorSmelser, Diane T
dc.contributor.authorSmith, Nicholas L
dc.contributor.authorStefansson, Kari
dc.contributor.authorStender, Steen
dc.contributor.authorStott, David J
dc.contributor.authorSveinbjörnsson, Garðar
dc.contributor.authorTammesoo, Mari-Liis
dc.contributor.authorTardif, Jean-Claude
dc.contributor.authorTaylor, Kent D
dc.contributor.authorTeder-Laving, Maris
dc.contributor.authorTeumer, Alexander
dc.contributor.authorThorgeirsson, Guðmundur
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorTorp-Pedersen, Christian
dc.contributor.authorTrompet, Stella
dc.contributor.authorTuckwell, Danny
dc.contributor.authorTyl, Benoit
dc.contributor.authorUitterlinden, Andre G
dc.contributor.authorVaura, Felix
dc.contributor.authorVeluchamy, Abirami
dc.contributor.authorVisscher, Peter M
dc.contributor.authorVölker, Uwe
dc.contributor.authorVoors, Adriaan A
dc.contributor.authorWang, Xiaosong
dc.contributor.authorWareham, Nicholas J
dc.contributor.authorWeeke, Peter E
dc.contributor.authorWeiss, Raul
dc.contributor.authorWhite, Harvey D
dc.contributor.authorWiggins, Kerri L
dc.contributor.authorXing, Heming
dc.contributor.authorYang, Jian
dc.contributor.authorYang, Yifan
dc.contributor.authorYerges-Armstrong, Laura M
dc.contributor.authorYu, Bing
dc.contributor.authorZannad, Faiez
dc.contributor.authorZhao, Faye
dc.contributor.authorWilk, Jemma B
dc.contributor.authorHolm, Hilma
dc.contributor.authorSattar, Naveed
dc.contributor.authorLubitz, Steven A
dc.contributor.authorLanfear, David E
dc.contributor.authorShah, Svati
dc.contributor.authorDunn, Michael E
dc.contributor.authorWells, Quinn S
dc.contributor.authorAsselbergs, Folkert W
dc.contributor.authorHingorani, Aroon D
dc.contributor.authorDubé, Marie-Pierre
dc.contributor.authorSamani, Nilesh J
dc.contributor.authorLang, Chim C
dc.contributor.authorCappola, Thomas P
dc.contributor.authorEllinor, Patrick T
dc.contributor.authorVasan, Ramachandran S
dc.contributor.authorSmith, J Gustav
dc.date.accessioned2021-09-13T17:06:49Z
dc.date.available2021-09-13T17:06:49Z
dc.date.issued2021-09-03
dc.identifier.urihttp://hdl.handle.net/10713/16610
dc.description.abstractAims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34–90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low-frequency variants (allele frequency 0.01–0.05) at P < 5 × 10−8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.en_US
dc.description.urihttps://doi.org/10.1002/ehf2.13517en_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofESC Heart Failureen_US
dc.rights© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.en_US
dc.subjectAssociation studiesen_US
dc.subjectBiomarkersen_US
dc.subjectCardiomyopathyen_US
dc.subjectGeneticsen_US
dc.subjectHeart failureen_US
dc.titleThe genomics of heart failure: design and rationale of the HERMES consortiumen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/ehf2.13517
dc.identifier.pmid34480422
dc.source.countryInternational
dc.source.countryUnited States
dc.source.countryEngland


This item appears in the following Collection(s)

Show simple item record