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dc.contributor.authorBlau, Dianna M
dc.contributor.authorBaillie, Vicky L
dc.contributor.authorEls, Toyah
dc.contributor.authorMahtab, Sana
dc.contributor.authorMutevedzi, Portia
dc.contributor.authorKeita, Adama Mamby
dc.contributor.authorKotloff, Karen L
dc.contributor.authorMehta, Ashka
dc.contributor.authorSow, Samba O
dc.contributor.authorTapia, Milagritos D
dc.contributor.authorTippett Barr, Beth A
dc.contributor.authorOluoch, Benard O
dc.contributor.authorOnyango, Clayton
dc.contributor.authorRevathi, Gunturu
dc.contributor.authorVerani, Jennifer R
dc.contributor.authorAbayneh, Mahlet
dc.contributor.authorAssefa, Nega
dc.contributor.authorMadrid, Lola
dc.contributor.authorOundo, Joseph O
dc.contributor.authorScott, J Anthony G
dc.contributor.authorBassat, Quique
dc.contributor.authorMandomando, Inacio
dc.contributor.authorSitoe, Antonio
dc.contributor.authorValente, Marta
dc.contributor.authorVaro, Rosauro
dc.contributor.authorBassey, Ima-Abasi
dc.contributor.authorCain, Carrie Jo
dc.contributor.authorJambai, Amara
dc.contributor.authorOgbuanu, Ikechukwu
dc.contributor.authorOjulong, Julius
dc.contributor.authorAlam, Muntasir
dc.contributor.authorEl Arifeen, Shams
dc.contributor.authorGurley, Emily S
dc.contributor.authorRahman, Afruna
dc.contributor.authorRahman, Mustafizur
dc.contributor.authorWaller, Jessica L
dc.contributor.authorDewey, Betsy
dc.contributor.authorBreiman, Robert F
dc.contributor.authorWhitney, Cynthia G
dc.contributor.authorMadhi, Shabir A
dc.date.accessioned2021-09-13T15:30:13Z
dc.date.available2021-09-13T15:30:13Z
dc.date.issued2021-09-02
dc.identifier.urihttp://hdl.handle.net/10713/16596
dc.description.abstractBackground: Lower respiratory tract infections are a leading cause of death in young children, but few studies have collected the specimens needed to define the role of specific causes. The Child Health and Mortality Prevention Surveillance (CHAMPS) platform aims to investigate causes of death in children aged <5 years in high-mortality rate settings, using postmortem minimally invasive tissue sampling and other advanced diagnostic techniques. We examined findings for deaths identified in CHAMPS sites in 7 countries in sub-Saharan Africa and south Asia to evaluate the role of respiratory syncytial virus (RSV). Methods: We included deaths that occurred between December 2016 and December 2019. Panels determined causes of deaths by reviewing all available data including pathological results from minimally invasive tissue sampling, polymerase chain reaction screening for multiple infectious pathogens in lung tissue, nasopharyngeal swab, blood, and cerebrospinal fluid samples, clinical information from medical records, and verbal autopsies. Results: We evaluated 1213 deaths, including 695 in neonates (aged <28 days), 283 in infants (28 days to <12 months), and 235 in children (12-59 months). RSV was detected in postmortem specimens in 67 of 1213 deaths (5.5%); in 24 deaths (2.0% of total), RSV was determined to be a cause of death, and it contributed to 5 other deaths. Younger infants (28 days to <6 months of age) accounted for half of all deaths attributed to RSV; 6.5% of all deaths in younger infants were attributed to RSV. RSV was the underlying and only cause in 4 deaths; the remainder (n = 20) had a median of 2 (range, 1-5) other conditions in the causal chain. Birth defects (n = 8) and infections with other pathogens (n = 17) were common comorbid conditions. Conclusions: RSV is an important cause of child deaths, particularly in young infants. These findings add to the substantial body of literature calling for better treatment and prevention options for RSV in high-mortality rate settings.en_US
dc.description.urihttps://doi.org/10.1093/cid/ciab509en_US
dc.description.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/pmc8411256/en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofClinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of Americaen_US
dc.rights© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.en_US
dc.subjectRespiratory syncytial virusen_US
dc.subjectcause of deathen_US
dc.subjectchild mortalityen_US
dc.titleDeaths Attributed to Respiratory Syncytial Virus in Young Children in High-Mortality Rate Settings: Report from Child Health and Mortality Prevention Surveillance (CHAMPS)en_US
dc.typeArticleen_US
dc.identifier.doi10.1093/cid/ciab509
dc.identifier.pmid34472577
dc.source.volume73
dc.source.issueSupplement_3
dc.source.beginpageS218
dc.source.endpageS228
dc.source.countryUnited States


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