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dc.contributor.authorKamel, Hooman
dc.contributor.authorBartz, Traci M
dc.contributor.authorLongstreth, W T
dc.contributor.authorElkind, Mitchell S V
dc.contributor.authorGottdiener, John
dc.contributor.authorKizer, Jorge R
dc.contributor.authorGardin, Julius M
dc.contributor.authorKim, Jiwon
dc.contributor.authorShah, Sanjiv
dc.date.accessioned2021-09-02T16:07:29Z
dc.date.available2021-09-02T16:07:29Z
dc.date.issued2021-08-30
dc.identifier.urihttp://hdl.handle.net/10713/16530
dc.description.abstractRecent evidence indicates that our understanding of the relationship between cardiac function and ischemic stroke remains incomplete. The Cardiovascular Health Study enrolled community-dwelling adults ≥ 65 years old. We included participants with speckle-tracking data from digitized baseline study echocardiograms. Exposures were left atrial reservoir strain (primary), left ventricular longitudinal strain, left ventricular early diastolic strain rate, septal e' velocity, and lateral e' velocity. The primary outcome was incident ischemic stroke. Cox proportional hazards models were adjusted for demographics, image quality, and risk factors including left ventricular ejection fraction and incident atrial fibrillation. Among 4,000 participants in our analysis, lower (worse) left atrial reservoir strain was associated with incident ischemic stroke (HR per SD absolute decrease, 1.14; 95% CI 1.04-25). All secondary exposure variables were significantly associated with the outcome. Left atrial reservoir strain was associated with cardioembolic stroke (HR per SD absolute decrease, 1.42; 95% CI 1.21-1.67) and cardioembolic stroke related to incident atrial fibrillation (HR per SD absolute decrease, 1.60; 1.32-1.95). Myocardial dysfunction that can ultimately lead to stroke may be identifiable at an early stage. This highlights opportunities to identify cerebrovascular risk earlier and improve stroke prevention via therapies for early myocardial dysfunction.en_US
dc.description.urihttps://doi.org/10.1038/s41598-021-96702-zen_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofScientific Reportsen_US
dc.rights© 2021. The Author(s).en_US
dc.subject.meshIschemic Strokeen_US
dc.subject.meshHeart Diseasesen_US
dc.titleCardiac mechanics and incident ischemic stroke: the Cardiovascular Health Studyen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41598-021-96702-z
dc.identifier.pmid34462469
dc.source.volume11
dc.source.issue1
dc.source.beginpage17358
dc.source.endpage
dc.source.countryEngland


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