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    Sulfa-induced acute eosinophilic pneumonia

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    Author
    Nasim, Faria
    Paul, Jose Antony
    Boland-Froemming, Jennifer
    Wylam, Mark E.
    Date
    2021-08-13
    Journal
    Respiratory Medicine Case Reports
    Publisher
    Elsevier Inc.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1016/j.rmcr.2021.101496
    Abstract
    Acute eosinophilic pneumonia (AEP) is an infrequently seen interstitial lung disease secondary to medications. We report a series of 3 case of severe AEP which developed as a result of sulfa medication. 2 patients had received treatment with sulfamethoxazole for acne and 1 was treated with sulfasalazine for colitis. Patients were on sulfa medication for 1–3 weeks prior to presentation. All patients presented with fever, acute onset bilateral pulmonary infiltrates as well as marked peripheral eosinophilia. Mean eosinophil count was 2.21 × 109/L. There was a lack of response to steroids. One patient required extracorporeal membrane oxygenation and prolonged mechanical ventilation via tracheostomy. 2 patients underwent successful lung transplantation (1 bilateral living-related lobar lung transplant and 1 orthotropic cardiopulmonary allotransplantation). In all cases lung biopsy and explants showed acute and organizing diffuse alveolar damage with increased interstitial and airspace eosinophils. To our knowledge, our series is the first to show the clinical features of sulfa induced AEP in an adolescent population.
    Keyword
    Acute eosinophilic pneumonia
    ECMO
    Lung transplant
    Sulfa-induced
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/16523
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.rmcr.2021.101496
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