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    Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans

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    Author
    Kehdy, Fernanda S G
    Pita-Oliveira, Murilo
    Scudeler, Mariana M
    Torres-Loureiro, Sabrina
    Zolini, Camila
    Moreira, Rennan
    Michelin, Lucas A
    Alvim, Isabela
    Silva-Carvalho, Carolina
    Furlan, Vinicius C
    Aquino, Marla M
    Santolalla, Meddly L
    Borda, Victor
    Soares-Souza, Giordano B
    Jaramillo-Valverde, Luis
    Vasquez-Dominguez, Andres
    Neira, Cesar Sanchez
    Aguiar, Renato S
    Verdugo, Ricardo A
    O Connor, Timothy D
    Guio, Heinner
    Tarazona-Santos, Eduardo
    Leal, Thiago P
    Rodrigues-Soares, Fernanda
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    Date
    2021-08-25
    Journal
    Genetics and Molecular Biology
    Publisher
    Sociedade Brasileira de Genética
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1590/1678-4685-GMB-2020-0484
    Abstract
    For human/SARS-CoV-2 interactome genes ACE2, TMPRSS2 and BSG, there is a convincing evidence of association in Asians with influenza-induced SARS for TMPRSS2-rs2070788, tag-SNP of the eQTL rs383510. This case illustrates the importance of population genetics and of sequencing data in the design of genetic association studies in different human populations: the high linkage disequilibrium (LD) between rs2070788 and rs383510 is Asian-specific. Leveraging on a combination of genotyping and sequencing data for Native Americans (neglected in genetic studies), we show that while their frequencies of the Asian tag-SNP rs2070788 is, surprisingly, the highest worldwide, it is not in LD with the eQTL rs383510, that therefore, should be directly genotyped in genetic association studies of SARS in populations with Native American ancestry.
    Keyword
    TMPRSS2
    ACE2
    Native Americans
    SARS-CoV-2
    population genomics
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/16505
    ae974a485f413a2113503eed53cd6c53
    10.1590/1678-4685-GMB-2020-0484
    Scopus Count
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