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dc.contributor.authorBalaphas, Alexandre
dc.contributor.authorMeyer, Jeremy
dc.contributor.authorMeier, Raphael P H
dc.contributor.authorLiot, Emilie
dc.contributor.authorBuchs, Nicolas C
dc.contributor.authorRoche, Bruno
dc.contributor.authorToso, Christian
dc.contributor.authorBühler, Leo H
dc.contributor.authorGonelle-Gispert, Carmen
dc.contributor.authorRis, Frédéric
dc.date.accessioned2021-08-30T16:53:57Z
dc.date.available2021-08-30T16:53:57Z
dc.date.issued2021-08-13
dc.identifier.urihttp://hdl.handle.net/10713/16496
dc.description.abstractAnal sphincter incontinence is a chronic disease, which dramatically impairs quality of life and induces high costs for the society. Surgery, considered as the best curative option, shows a disappointing success rate. Stem/progenitor cell therapy is pledging, for anal sphincter incontinence, a substitute to surgery with higher efficacy. However, the published literature is disparate. Our aim was to perform a review on the development of cell therapy for anal sphincter incontinence with critical analyses of its pitfalls. Animal models for anal sphincter incontinence were varied and tried to reproduce distinct clinical situations (acute injury or healed injury with or without surgical reconstruction) but were limited by anatomical considerations. Cell preparations used for treatment, originated, in order of frequency, from skeletal muscle, bone marrow or fat tissue. The characterization of these preparations was often incomplete and stemness not always addressed. Despite a lack of understanding of sphincter healing processes and the exact mechanism of action of cell preparations, this treatment was evaluated in 83 incontinent patients, reporting encouraging results. However, further development is necessary to establish the correct indications, to determine the most-suited cell type, to standardize the cell preparation method and to validate the route and number of cell delivery.en_US
dc.description.urihttps://doi.org/10.3390/cells10082086en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofCellsen_US
dc.subjectanal incontinenceen_US
dc.subjectfecal incontinenceen_US
dc.subjectmesenchymal stem cellen_US
dc.subjectmesenchymal stromal cellen_US
dc.subjectmulitipotent cellen_US
dc.subjectmyoblasten_US
dc.subjectprogenitor cellen_US
dc.subjectsatellite cellen_US
dc.subjectstem cellen_US
dc.titleCell Therapy for Anal Sphincter Incontinence: Where Do We Stand?en_US
dc.typeArticleen_US
dc.identifier.doi10.3390/cells10082086
dc.identifier.pmid34440855
dc.source.volume10
dc.source.issue8
dc.source.countrySwitzerland


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