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dc.contributor.authorHasan, S. Saif
dc.contributor.authorDey, Debajit
dc.contributor.authorSingh, Suruchi
dc.contributor.authorMartin, Matthew
dc.date.accessioned2021-08-24T17:59:54Z
dc.date.available2021-08-24T17:59:54Z
dc.date.issued2021-07-31
dc.identifier.urihttp://hdl.handle.net/10713/16456
dc.description.abstractAlphaviruses are arboviruses that cause arthritis and encephalitis in humans. Eastern Equine Encephalitis Virus (EEEV) is a mosquito-transmitted alphavirus that is implicated in severe encephalitis in humans with high mortality. However, limited insights are available into the fundamental biology of EEEV and residue-level details of its interactions with host proteins. In recent years, outbreaks of EEEV have been reported mainly in the United States, raising concerns about public safety. This review article summarizes recent advances in the structural biology of EEEV based mainly on single-particle cryogenic electron microscopy (cryoEM) structures. Together with functional analyses of EEEV and related alphaviruses, these structural investigations provide clues to how EEEV interacts with host proteins, which may open avenues for the development of therapeutics.en_US
dc.description.sponsorshipSchool of Medicine, University of Marylanden_US
dc.description.urihttps://doi.org/10.3390/pathogens10080973en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofPathogens (Basel, Switzerland)en_US
dc.subjectAlphavirusen_US
dc.subjectAntibodyen_US
dc.subjectAssemblyen_US
dc.subjectEastern equine encephalitis virusen_US
dc.subjectStructureen_US
dc.titleThe structural biology of eastern equine encephalitis virus, an emerging viral threaten_US
dc.typeArticleen_US
dc.identifier.doi10.3390/pathogens10080973
dc.source.volume10
dc.source.issue8


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