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    The structural biology of eastern equine encephalitis virus, an emerging viral threat

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    Author
    Hasan, S. Saif
    Dey, Debajit
    Singh, Suruchi
    Martin, Matthew
    Date
    2021-07-31
    Journal
    Pathogens (Basel, Switzerland)
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/pathogens10080973
    Abstract
    Alphaviruses are arboviruses that cause arthritis and encephalitis in humans. Eastern Equine Encephalitis Virus (EEEV) is a mosquito-transmitted alphavirus that is implicated in severe encephalitis in humans with high mortality. However, limited insights are available into the fundamental biology of EEEV and residue-level details of its interactions with host proteins. In recent years, outbreaks of EEEV have been reported mainly in the United States, raising concerns about public safety. This review article summarizes recent advances in the structural biology of EEEV based mainly on single-particle cryogenic electron microscopy (cryoEM) structures. Together with functional analyses of EEEV and related alphaviruses, these structural investigations provide clues to how EEEV interacts with host proteins, which may open avenues for the development of therapeutics.
    Sponsors
    School of Medicine, University of Maryland
    Keyword
    Alphavirus
    Antibody
    Assembly
    Eastern equine encephalitis virus
    Structure
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/16456
    ae974a485f413a2113503eed53cd6c53
    10.3390/pathogens10080973
    Scopus Count
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