• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Compounds Isolated from Regulate Bone Remodeling by Modulating Osteoblast and Osteoclast Activities

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Imtiyaz, Zuha
    Lin, Yi-Tzu
    Liang, Fang-Yu
    Chiou, Wen-Fei
    Lee, Mei-Hsien
    Date
    2021-07-13
    Journal
    Frontiers in Pharmacology
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fphar.2021.670254
    Abstract
    Bone remodeling, a dynamic process in which bone formation by osteoblast is preceded by bone resorption by osteoclast, is a vital physiological process for maintaining bone mass and strength, imbalances in which could precipitate osteoporosis. Due to the unilateral mechanism of the existing bone remodeling drugs, identifying compounds that could regulate the balance between osteoclast and osteoblast could improve the treatment of osteoporosis. Here, we show that compounds isolated from Wikstroemia taiwanensis modulate osteoclast and osteoblast activities. Specifically, astragalin (1) and kaempferol 3-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (2), besides increasing mineral deposition, increased alkaline phosphatase activity (137.2% for 1 and 115.8% for 2) and ESR-α expression (112.8% for 1 and 122.5% for 2) in primary human osteoblasts. In contrast, compounds 1, 2, 3, and 5 inhibited tartrate-resistant acid phosphatase (TRAP) activity in receptor activator of nuclear factor-κB ligand-induced osteoclasts by 40.8, 17.1, 25.9, and 14.5% and also decreased the number of TRAP-positive cells by 51.6, 26.8, 20.5, and 18.6%, respectively. Our findings, therefore, showed that compounds isolated from W. taiwanensis could increase osteoblast activity while simultaneously decreasing osteoclast activity, and hence, warrant further evaluation for development as anti-osteoporosis agents.
    Rights/Terms
    Copyright © 2021 Imtiyaz, Lin, Liang, Chiou and Lee.
    Keyword
    Wikstroemia taiwanensis
    astragalin
    bone remodeling
    kaempferol 3-O-β-d-apiofuranosyl-(1→6)-β-d-glucopyranoside
    osteoblasts
    osteoclasts
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/16351
    ae974a485f413a2113503eed53cd6c53
    10.3389/fphar.2021.670254
    Scopus Count
    Collections
    UMB Open Access Articles

    entitlement

    Related articles

    • WHI-131 Promotes Osteoblast Differentiation and Prevents Osteoclast Formation and Resorption in Mice.
    • Authors: Cheon YH, Kim JY, Baek JM, Ahn SJ, Jun HY, Erkhembaatar M, Kim MS, Lee MS, Oh J
    • Issue date: 2016 Feb
    • Rev-erbα Negatively Regulates Osteoclast and Osteoblast Differentiation through p38 MAPK Signaling Pathway.
    • Authors: Kim K, Kim JH, Kim I, Seong S, Kim N
    • Issue date: 2020 Jan 31
    • Emodin regulates bone remodeling by inhibiting osteoclastogenesis and stimulating osteoblast formation.
    • Authors: Kim JY, Cheon YH, Kwak SC, Baek JM, Yoon KH, Lee MS, Oh J
    • Issue date: 2014 Jul
    • Poligoni Multiflori Radix enhances osteoblast formation and reduces osteoclast differentiation.
    • Authors: Han SY, Lee KH, Kim YK
    • Issue date: 2018 Jul
    • Coenzyme q10 regulates osteoclast and osteoblast differentiation.
    • Authors: Moon HJ, Ko WK, Jung MS, Kim JH, Lee WJ, Park KS, Heo JK, Bang JB, Kwon IK
    • Issue date: 2013 May
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.