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    SARS-CoV-2 and Acute Cerebrovascular Events: An Overview

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    Author
    Ghasemi, Mehdi
    Umeton, Raffaella Pizzolato
    Keyhanian, Kiandokht
    Mohit, Babak
    Rahimian, Nasrin
    Eshaghhosseiny, Niloofarsadaat
    Davoudi, Vahid
    Date
    2021-07-29
    Journal
    Journal of Clinical Medicine
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/jcm10153349
    Abstract
    Since the coronavirus disease 2019 (COVID-19) pandemic, due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, accumulating evidence indicates that SARS-CoV-2 infection may be associated with various neurological manifestations, including acute cerebrovascular events (i.e., stroke and cerebral venous thrombosis). These events can occur prior to, during and even after the onset of COVID-19's general symptoms. Although the mechanisms underlying the cerebrovascular complications in patients with COVID-19 are yet to be fully elucidated, the hypercoagulability state, inflammation and altered angiotensin-converting enzyme 2 (ACE-2) signaling in association with SARS-CoV-2 may play key roles. ACE-2 plays a critical role in preserving heart and brain homeostasis. In this review, we discuss the current state of knowledge of the possible mechanisms underlying the acute cerebrovascular events in patients with COVID-19, and we review the current epidemiological studies and case reports of neurovascular complications in association with SARS-CoV-2, as well as the relevant therapeutic approaches that have been considered worldwide. As the number of published COVID-19 cases with cerebrovascular events is growing, prospective studies would help gather more valuable insights into the pathophysiology of cerebrovascular events, effective therapies, and the factors predicting poor functional outcomes related to such events in COVID-19 patients.
    Keyword
    angiotensin-converting enzyme 2 (ACE-2)
    cerebral venous thrombosis
    coronavirus disease 2019 (COVID-19)
    hypercoagulability
    severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
    stroke
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/16348
    ae974a485f413a2113503eed53cd6c53
    10.3390/jcm10153349
    Scopus Count
    Collections
    UMB Coronavirus Publications
    UMB Open Access Articles

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