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dc.contributor.authorYang, Chaojie
dc.contributor.authorHallmark, Brian
dc.contributor.authorChai, Jin Choul
dc.contributor.authorO'Connor, Timothy D
dc.contributor.authorReynolds, Lindsay M
dc.contributor.authorWood, Alexis C
dc.contributor.authorSeeds, Michael
dc.contributor.authorChen, Yii-Der Ida
dc.contributor.authorSteffen, Lyn M
dc.contributor.authorTsai, Michael Y
dc.contributor.authorKaplan, Robert C
dc.contributor.authorDaviglus, Martha L
dc.contributor.authorMandarino, Lawrence J
dc.contributor.authorFretts, Amanda M
dc.contributor.authorLemaitre, Rozenn N
dc.contributor.authorColetta, Dawn K
dc.contributor.authorBlomquist, Sarah A
dc.contributor.authorJohnstone, Laurel M
dc.contributor.authorTontsch, Chandra
dc.contributor.authorQi, Qibin
dc.contributor.authorRuczinski, Ingo
dc.contributor.authorRich, Stephen S
dc.contributor.authorMathias, Rasika A
dc.contributor.authorChilton, Floyd H
dc.contributor.authorManichaikul, Ani
dc.date.accessioned2021-08-03T16:02:39Z
dc.date.available2021-08-03T16:02:39Z
dc.date.issued2021-07-28
dc.identifier.urihttp://hdl.handle.net/10713/16295
dc.description.abstractLong chain polyunsaturated fatty acids (LC-PUFAs) have critical signaling roles that regulate dyslipidemia and inflammation. Genetic variation in the FADS gene cluster accounts for a large portion of interindividual differences in circulating and tissue levels of LC-PUFAs, with the genotypes most strongly predictive of low LC-PUFA levels at strikingly higher frequencies in Amerind ancestry populations. In this study, we examined relationships between genetic ancestry and FADS variation in 1102 Hispanic American participants from the Multi-Ethnic Study of Atherosclerosis. We demonstrate strong negative associations between Amerind genetic ancestry and LC-PUFA levels. The FADS rs174537 single nucleotide polymorphism (SNP) accounted for much of the AI ancestry effect on LC-PUFAs, especially for low levels of n-3 LC-PUFAs. Rs174537 was also strongly associated with several metabolic, inflammatory and anthropomorphic traits including circulating triglycerides (TGs) and E-selectin in MESA Hispanics. Our study demonstrates that Amerind ancestry provides a useful and readily available tool to identify individuals most likely to have FADS-related n-3 LC-PUFA deficiencies and associated cardiovascular risk.en_US
dc.description.urihttps://doi.org/10.1038/s42003-021-02431-4en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofCommunications Biologyen_US
dc.rights© 2021. The Author(s).en_US
dc.subjectAmerind ancestryen_US
dc.subject.meshHeart Disease Risk Factorsen_US
dc.subject.meshHispanic Americans--geneticsen_US
dc.titleImpact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populationsen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s42003-021-02431-4
dc.identifier.pmid34321601
dc.source.volume4
dc.source.issue1
dc.source.beginpage918
dc.source.endpage
dc.source.countryUnited States
dc.source.countryEngland


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