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dc.contributor.authorLi, Lushen
dc.contributor.authorWu, Jing
dc.contributor.authorAbdi, Reza
dc.contributor.authorJewell, Christopher M
dc.contributor.authorBromberg, Jonathan S
dc.date.accessioned2021-07-29T18:10:08Z
dc.date.available2021-07-29T18:10:08Z
dc.date.issued2021-07-10
dc.identifier.urihttp://hdl.handle.net/10713/16263
dc.description.abstractLymph nodes (LNs), where immune responses are initiated, are organized into distinctive compartments by fibroblastic reticular cells (FRCs). FRCs imprint immune responses by supporting LN architecture, recruiting immune cells, coordinating immune cell crosstalk, and presenting antigens. Recent high-resolution transcriptional and histological analyses have enriched our knowledge of LN FRC genetic and spatial heterogeneities. Here, we summarize updated anatomic, phenotypic, and functional identities of FRC subsets, delve into topological and transcriptional remodeling of FRCs in inflammation, and illustrate the crosstalk between FRCs and immune cells. Discussing FRC functions in immunity and tolerance, we highlight state-of-the-art FRC-based therapeutic approaches for maintaining physiological homeostasis, steering protective immunity, inducing transplantation tolerance, and treating diverse immune-related diseases. © 2021en_US
dc.description.urihttps://doi.org/10.1016/j.it.2021.06.006en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofTrends in Immunologyen_US
dc.rightsPublished by Elsevier Ltd.en_US
dc.subjectfibroblastic reticular cellsen_US
dc.subjectimmunityen_US
dc.subjectlymph nodesen_US
dc.subjecttoleranceen_US
dc.titleLymph node fibroblastic reticular cells steer immune responsesen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.it.2021.06.006
dc.identifier.pmid34256989
dc.source.countryEngland


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