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Date
2021-07-10Journal
Trends in ImmunologyPublisher
Elsevier Ltd.Type
Article
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Lymph nodes (LNs), where immune responses are initiated, are organized into distinctive compartments by fibroblastic reticular cells (FRCs). FRCs imprint immune responses by supporting LN architecture, recruiting immune cells, coordinating immune cell crosstalk, and presenting antigens. Recent high-resolution transcriptional and histological analyses have enriched our knowledge of LN FRC genetic and spatial heterogeneities. Here, we summarize updated anatomic, phenotypic, and functional identities of FRC subsets, delve into topological and transcriptional remodeling of FRCs in inflammation, and illustrate the crosstalk between FRCs and immune cells. Discussing FRC functions in immunity and tolerance, we highlight state-of-the-art FRC-based therapeutic approaches for maintaining physiological homeostasis, steering protective immunity, inducing transplantation tolerance, and treating diverse immune-related diseases. © 2021Rights/Terms
Published by Elsevier Ltd.Identifier to cite or link to this item
http://hdl.handle.net/10713/16263ae974a485f413a2113503eed53cd6c53
10.1016/j.it.2021.06.006
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