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    Lymph node fibroblastic reticular cells steer immune responses

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    Author
    Li, Lushen
    Wu, Jing
    Abdi, Reza
    Jewell, Christopher M
    Bromberg, Jonathan S
    Date
    2021-07-10
    Journal
    Trends in Immunology
    Publisher
    Elsevier Ltd.
    Type
    Article
    
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    See at
    https://doi.org/10.1016/j.it.2021.06.006
    Abstract
    Lymph nodes (LNs), where immune responses are initiated, are organized into distinctive compartments by fibroblastic reticular cells (FRCs). FRCs imprint immune responses by supporting LN architecture, recruiting immune cells, coordinating immune cell crosstalk, and presenting antigens. Recent high-resolution transcriptional and histological analyses have enriched our knowledge of LN FRC genetic and spatial heterogeneities. Here, we summarize updated anatomic, phenotypic, and functional identities of FRC subsets, delve into topological and transcriptional remodeling of FRCs in inflammation, and illustrate the crosstalk between FRCs and immune cells. Discussing FRC functions in immunity and tolerance, we highlight state-of-the-art FRC-based therapeutic approaches for maintaining physiological homeostasis, steering protective immunity, inducing transplantation tolerance, and treating diverse immune-related diseases. © 2021
    Rights/Terms
    Published by Elsevier Ltd.
    Keyword
    fibroblastic reticular cells
    immunity
    lymph nodes
    tolerance
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/16263
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.it.2021.06.006
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