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dc.contributor.authorGoldwaser, Eric L
dc.contributor.authorChiappelli, Joshua
dc.contributor.authorKvarta, Mark D
dc.contributor.authorDu, Xiaoming
dc.contributor.authorMillman, Zachary B
dc.contributor.authorAdhikari, Bhim M
dc.contributor.authorO'Neill, Hugh
dc.contributor.authorSewell, Jessica
dc.contributor.authorLightner, Samantha
dc.contributor.authorVodapalli, Shreya
dc.contributor.authorMa, Yizhou
dc.contributor.authorBruce, Heather
dc.contributor.authorChen, Shuo
dc.contributor.authorTan, Yunlong
dc.contributor.authorKochunov, Peter
dc.contributor.authorElliot Hong, L
dc.date.accessioned2021-07-16T12:43:35Z
dc.date.available2021-07-16T12:43:35Z
dc.date.issued2021-07-01
dc.identifier.urihttp://hdl.handle.net/10713/16195
dc.description.abstractStress is implicated in psychosis etiology and exacerbation, but pathogenesis toward brain network alterations in schizophrenia remain unclear. White matter connects limbic and prefrontal regions responsible for stress response regulation, and white matter tissues are also vulnerable to glucocorticoid aberrancies. Using a novel psychological stressor task, we studied cortisol stress responses over time and white matter microstructural deficits in schizophrenia spectrum disorder (SSD). Cortisol was measured at baseline, 0-, 20-, and 40-min after distress induction by a psychological stressor task in 121 SSD patients and 117 healthy controls (HC). White matter microstructural integrity was measured by 64-direction diffusion tensor imaging. Fractional anisotropy (FA) in white matter tracts were related to cortisol responses and then compared to general patterns of white matter tract deficits in SSD identified by mega-analysis. Differences between 40-min post-stress and baseline, but not acute reactivity post-stress, was significantly elevated in SSD vs HC, time × diagnosis interaction F2.3,499.9 = 4.1, p = 0.013. All SSD white matter tracts were negatively associated with prolonged cortisol reactivity but all tracts were positively associated with prolonged cortisol reactivity in HC. Individual tracts most strongly associated with prolonged cortisol reactivity were also most impacted in schizophrenia in general as established by the largest schizophrenia white matter study (r = -0.56, p = 0.006). Challenged with psychological stress, SSD and HC mount similar cortisol responses, and impairments arise in the resolution timeframe. Prolonged cortisol elevations are associated with the white matter deficits in SSD, in a pattern previously associated with schizophrenia in general.en_US
dc.description.urihttps://doi.org/10.1038/s41386-021-01077-4en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofNeuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacologyen_US
dc.subjectcortisolen_US
dc.subjectschizophrenia spectrum disorderen_US
dc.subject.meshHydrocortisoneen_US
dc.subject.meshSchizophrenia Spectrum and Other Psychotic Disordersen_US
dc.subject.meshWhite Matteren_US
dc.titleWhite matter in prolonged glucocorticoid response to psychological stress in schizophrenia.en_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41386-021-01077-4
dc.identifier.pmid34211106
dc.source.journaltitleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
dc.source.countryEngland


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