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dc.contributor.authorLee, Kun Tsung
dc.contributor.authorGuo, Zhu Ling
dc.contributor.authorTeng, Nai Chia
dc.contributor.authorHsu, Kuei Ling Christine
dc.contributor.authorChen, I. Hui
dc.contributor.authorLee, Chang Yu
dc.contributor.authorChang, Hung Ming
dc.contributor.authorHuang, Yung Kai
dc.date.accessioned2021-07-15T20:30:00Z
dc.date.available2021-07-15T20:30:00Z
dc.date.issued2021-07-02
dc.identifier.urihttp://hdl.handle.net/10713/16192
dc.description.abstractBackground: Hypertension and periodontal diseases share several risk factors. Inflammation biomarkers in saliva are related to hypertension and periodontal disease. The aim of this study was to explore the role of the salivary inflammatory biomarkers in the treatment effectiveness of patients with hypertension and periodontal disease. Methods: This observational study enrolled 160 subjects diagnosed with periodontitis, 40 of which had a history of hypertension. All subjects had completed scaling and root planning therapeutic procedures within four weeks. The clinical periodontal parameters (i.e., bleeding on probing, plaque control record (PCR), and probing depth (PD)) were evaluated before and after the treatment. Pro-inflammatory markers were determined using a commercial kit. Results: The recovery rate (PD 4–9 mm) in non-hypertensive subjects was significantly higher than in hypertensive subjects (60.47% vs. 52.60%, respectively; p = 0.04). All clinical parameters, excluding PCR, positively correlated with salivary IL-1β at baseline and after completing treatment. Our results showed that increased salivary IL-1β levels were positively associated with decreased PCR (β = −27.65 and p = 0.05) and PD recovery rate (β = −17.05 and p = 0.02) in hypertensive subjects. Conclusions: The present study sheds important light on the clinical use of salivary pro-inflammatory cytokines as valuable biomarkers for predicting the treatment effectiveness of patients suffering from hypertension and periodontitis. © 2021 by the authors.en_US
dc.description.sponsorshipMinistry of Science and Technology, Taiwanen_US
dc.description.urihttps://doi.org/10.3390/ijerph18147364en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofInternational Journal of Environmental Research and Public Healthen_US
dc.subjectCytokine(s)en_US
dc.subjectInflammation and innate immunityen_US
dc.subjectNon-surgical periodontal therapyen_US
dc.subjectPlaque controlen_US
dc.subjectScaling and root planningen_US
dc.titleSalivary pro-inflammatory markers and smoking status influences the treatment effectiveness of periodontal disease patients with hypertensionen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ijerph18147364
dc.source.volume18
dc.source.issue14


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