Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study
Author
Baillie, Vicky LMoore, David P
Mathunjwa, Azwifarwi
Baggett, Henry C
Brooks, Abdullah
Feikin, Daniel R
Hammitt, Laura L
Howie, Stephen R C
Knoll, Maria Deloria
Kotloff, Karen L
Levine, Orin S
O'Brien, Katherine L
Scott, Anthony G
Thea, Donald M
Antonio, Martin
Awori, Juliet O
Driscoll, Amanda J
Fancourt, Nicholas S S
Higdon, Melissa M
Karron, Ruth A
Morpeth, Susan C
Mulindwa, Justin M
Murdoch, David R
Park, Daniel E
Prosperi, Christine
Rahman, Mohammed Ziaur
Rahman, Mustafizur
Salaudeen, Rasheed A
Sawatwong, Pongpun
Somwe, Somwe Wa
Sow, Samba O
Tapia, Milagritos D
Simões, Eric A F
Madhi, Shabir A
Date
2021-06-27Journal
VirusesPublisher
MDPI AGType
Article
Metadata
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Rhinovirus (RV) is commonly detected in asymptomatic children; hence, its pathogenicity during childhood pneumonia remains controversial. We evaluated RV epidemiology in HIV-uninfected children hospitalized with clinical pneumonia and among community controls. PERCH was a case-control study that enrolled children (1-59 months) hospitalized with severe and very severe pneumonia per World Health Organization clinical criteria and age-frequency-matched community controls in seven countries. Nasopharyngeal/oropharyngeal swabs were collected for all participants, combined, and tested for RV and 18 other respiratory viruses using the Fast Track multiplex real-time PCR assay. RV detection was more common among cases (24%) than controls (21%) (aOR = 1.5, 95%CI:1.3-1.6). This association was driven by the children aged 12-59 months, where 28% of cases vs. 18% of controls were RV-positive (aOR = 2.1, 95%CI:1.8-2.5). Wheezing was 1.8-fold (aOR 95%CI:1.4-2.2) more prevalent among pneumonia cases who were RV-positive vs. RV-negative. Of the RV-positive cases, 13% had a higher probability (>75%) that RV was the cause of their pneumonia based on the PERCH integrated etiology analysis; 99% of these cases occurred in children over 12 months in Bangladesh. RV was commonly identified in both cases and controls and was significantly associated with severe pneumonia status among children over 12 months of age, particularly those in Bangladesh. RV-positive pneumonia was associated with wheezing.Identifier to cite or link to this item
http://hdl.handle.net/10713/16170ae974a485f413a2113503eed53cd6c53
10.3390/v13071249
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