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dc.contributor.authorClausen, Malene M
dc.contributor.authorVogelius, Ivan R
dc.contributor.authorKjær, Andreas
dc.contributor.authorBentzen, Søren M
dc.date.accessioned2021-07-12T13:20:24Z
dc.date.available2021-07-12T13:20:24Z
dc.date.issued2020-12-01
dc.identifier.urihttp://hdl.handle.net/10713/16164
dc.description.abstractPositron emission tomography (PET) imaging with 2-deoxy-2-[18F]-fluorodeoxyglucose (FDG) was proposed as prognostic marker in radiotherapy. Various uptake metrics and cut points were used, potentially leading to inflated effect estimates. Here, we performed a meta-analysis and systematic review of the prognostic value of pretreatment FDG-PET in head and neck squamous cell carcinoma (HNSCC) and non-small cell lung cancer (NSCLC), with tests for publication bias. Hazard ratio (HR) for overall survival (OS), disease free survival (DFS), and local control was extracted or derived from the 57 studies included. Test for publication bias was performed, and the number of statistical tests and cut-point optimizations were registered. Eggers regression related to correlation of SUVmax with OS/DFS yielded p = 0.08/p = 0.02 for HNSCC and p < 0.001/p = 0.014 for NSCLC. No outcomes showed significant correlation with SUVmax, when adjusting for publication bias effect, whereas all four showed a correlation in the conventional meta-analysis. The number of statistical tests and cut points were high with no indication of improvement over time. Our analysis showed significant evidence of publication bias leading to inflated estimates of the prognostic value of SUVmax. We suggest that improved management of these complexities, including predefined statistical analysis plans, are critical for a reliable assessment of FDG-PET.en_US
dc.description.urihttps://doi.org/10.3390/diagnostics10121030en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofDiagnostics (Basel, Switzerland)en_US
dc.subjectFDG–PET/CTen_US
dc.subjectHNSCCen_US
dc.subjectNSCLCen_US
dc.subjectprognosticationen_US
dc.subjectpublication biasen_US
dc.titleMultiple Testing, Cut-Point Optimization, and Signs of Publication Bias in Prognostic FDG-PET Imaging Studies of Head and Neck and Lung Cancer: A Review and Meta-Analysisen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/diagnostics10121030
dc.identifier.pmid33271785
dc.source.volume10
dc.source.issue12
dc.source.countrySwitzerland


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