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dc.contributor.authorWhittle, Nigel
dc.contributor.authorFadok, Jonathan
dc.contributor.authorMacPherson, Kathryn P
dc.contributor.authorNguyen, Robin
dc.contributor.authorBotta, Paolo
dc.contributor.authorWolff, Steffen B E
dc.contributor.authorMüller, Christian
dc.contributor.authorHerry, Cyril
dc.contributor.authorTovote, Philip
dc.contributor.authorHolmes, Andrew
dc.contributor.authorSingewald, Nicolas
dc.contributor.authorLüthi, Andreas
dc.contributor.authorCiocchi, Stéphane
dc.date.accessioned2021-07-09T12:35:32Z
dc.date.available2021-07-09T12:35:32Z
dc.date.issued2021-07-06
dc.identifier.urihttp://hdl.handle.net/10713/16155
dc.description.abstractFear extinction is an adaptive process whereby defensive responses are attenuated following repeated experience of prior fear-related stimuli without harm. The formation of extinction memories involves interactions between various corticolimbic structures, resulting in reduced central amygdala (CEA) output. Recent studies show, however, the CEA is not merely an output relay of fear responses but contains multiple neuronal subpopulations that interact to calibrate levels of fear responding. Here, by integrating behavioural, in vivo electrophysiological, anatomical and optogenetic approaches in mice we demonstrate that fear extinction produces reversible, stimulus- and context-specific changes in neuronal responses to conditioned stimuli in functionally and genetically defined cell types in the lateral (CEl) and medial (CEm) CEA. Moreover, we show these alterations are absent when extinction is deficient and that selective silencing of protein kinase C delta-expressing (PKCδ) CEl neurons impairs fear extinction. Our findings identify CEA inhibitory microcircuits that act as critical elements within the brain networks mediating fear extinction.en_US
dc.description.urihttps://doi.org/10.1038/s41467-021-24068-xen_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofNature Communicationsen_US
dc.subjectfear extinctionen_US
dc.subjectmicro-circuitsen_US
dc.subject.meshCentral Amygdaloid Nucleusen_US
dc.subject.meshFear--physiologyen_US
dc.titleCentral amygdala micro-circuits mediate fear extinctionen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41467-021-24068-x
dc.identifier.pmid34230461
dc.source.volume12
dc.source.issue1
dc.source.beginpage4156
dc.source.endpage
dc.source.countryEngland


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