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dc.contributor.authorFacadio Antero, Maria
dc.contributor.authorSingh, Bhuchitra
dc.contributor.authorPradhan, Apoorva
dc.contributor.authorGornet, Megan
dc.contributor.authorKearns, William G
dc.contributor.authorBaker, Valerie
dc.contributor.authorChristianson, Mindy S
dc.date.accessioned2021-07-07T16:47:15Z
dc.date.available2021-07-07T16:47:15Z
dc.date.issued2020-12-09
dc.identifier.urihttp://hdl.handle.net/10713/16142
dc.description.abstractObjective: To determine whether in vitro fertilization (IVF) with preimplantation genetic testing for aneuploidy (PGT-A) is cost effective to achieve a live birth compared with IVF alone in fresh donor oocyte cycles. Design: Theoretical cost-effectiveness study. Setting: Not applicable. Patients: None. Interventions: Comparison between the cost of IVF with PGT-A vs. IVF alone to achieve a live birth. The model analyzed a hypothetical single fresh oocyte donor IVF cycle with PGT-A vs. IVF alone and followed the progression of a single embryo through the different decision nodes. Cost estimates assigned to each clinical event were based on data obtained from the literature and institutional costs. Main outcome measures: Cost per live birth. Results: In the base-case analysis, IVF with PGT-A was not cost effective in fresh donor oocyte cycles when compared with IVF alone to achieve a live birth. The cycles using PGT-A cost an additional $6,018.66. The incremental cost-effectiveness ratio was found to be $119,606.59 per additional live birth achieved with IVF with PGT-A. Monte Carlo simulations demonstrated that IVF with PGT-A was not cost effective in nearly all iterations. Conclusions: PGT-A in fresh donor oocyte IVF cycles is not cost effective compared with IVF alone over a wide range of probabilities and costs.en_US
dc.description.urihttps://doi.org/10.1016/j.xfre.2020.11.005en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofF&S Reportsen_US
dc.rights© 2020 The Author(s).en_US
dc.subjectOocyte donoren_US
dc.subjectcost effectiveen_US
dc.subjectpreimplantation genetic testingen_US
dc.titleCost-effectiveness of preimplantation genetic testing for aneuploidy for fresh donor oocyte cyclesen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.xfre.2020.11.005
dc.identifier.pmid34223271
dc.source.volume2
dc.source.issue1
dc.source.beginpage36
dc.source.endpage42
dc.source.countryUnited States


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