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dc.contributor.authorAhmed, Nabid
dc.contributor.authorGandhi, Dheeraj
dc.contributor.authorMelhem, Elias R
dc.contributor.authorFrenkel, Victor
dc.date.accessioned2021-07-07T16:26:57Z
dc.date.available2021-07-07T16:26:57Z
dc.date.issued2021-06-17
dc.identifier.urihttp://hdl.handle.net/10713/16139
dc.description.abstractStem cell and immune cell therapies are being investigated as a potential therapeutic modality for CNS disorders, performing functions such as targeted drug or growth factor delivery, tumor cell destruction, or inflammatory regulation. Despite promising preclinical studies, delivery routes for maximizing cell engraftment, such as stereotactic or intrathecal injection, are invasive and carry risks of hemorrhage and infection. Recent developments in MRI-guided focused ultrasound (MRgFUS) technology have significant implications for treating focal CNS pathologies including neurodegenerative, vascular and malignant processes. MRgFUS is currently employed in the clinic for treating essential tremor and Parkinson's Disease by producing precise, incisionless, transcranial lesions. This non-invasive technology can also be modified for non-destructive applications to safely and transiently open the blood-brain barrier (BBB) to deliver a range of therapeutics, including cells. This review is meant to familiarize the neuro-interventionalist with this topic and discusses the use of MRgFUS for facilitating cellular delivery to the brain. A detailed and comprehensive description is provided on routes of cell administration, imaging strategies for targeting and tracking cellular delivery and engraftment, biophysical mechanisms of BBB enhanced permeability, supportive proof-of-concept studies, and potential for clinical translation.en_US
dc.description.urihttps://doi.org/10.3389/fneur.2021.669449en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Neurologyen_US
dc.rightsCopyright © 2021 Ahmed, Gandhi, Melhem and Frenkel.en_US
dc.subjectMRI-guided focused ultrasounden_US
dc.subjectblood-brain barrieren_US
dc.subjectcellular therapyen_US
dc.subjectcellular trackingen_US
dc.subjectcentral nervous system diseasesen_US
dc.titleMRI Guided Focused Ultrasound-Mediated Delivery of Therapeutic Cells to the Brain: A Review of the State-of-the-Art Methodology and Future Applicationsen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fneur.2021.669449
dc.identifier.pmid34220679
dc.source.volume12
dc.source.beginpage669449
dc.source.endpage
dc.source.countrySwitzerland


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