Show simple item record

dc.contributor.authorCornelissen, Anne
dc.contributor.authorFuller, Daniela T
dc.contributor.authorFernandez, Raquel
dc.contributor.authorZhao, Xiaoqing
dc.contributor.authorKutys, Robert
dc.contributor.authorBinns-Roemer, Elizabeth
dc.contributor.authorDelsante, Marco
dc.contributor.authorSakamoto, Atsushi
dc.contributor.authorPaek, Ka Hyun
dc.contributor.authorSato, Yu
dc.contributor.authorKawakami, Rika
dc.contributor.authorMori, Masayuki
dc.contributor.authorKawai, Kenji
dc.contributor.authorYoshida, Teruhiko
dc.contributor.authorLatt, Khun Zaw
dc.contributor.authorMiller, Clint L
dc.contributor.authorde Vries, Paul S
dc.contributor.authorKolodgie, Frank D
dc.contributor.authorVirmani, Renu
dc.contributor.authorShin, Myung Kyun
dc.contributor.authorHoek, Maarten
dc.contributor.authorHeymann, Jurgen
dc.contributor.authorKopp, Jeffrey B
dc.contributor.authorRosenberg, Avi Z
dc.contributor.authorDavis, Harry R
dc.contributor.authorGuo, Liang
dc.contributor.authorFinn, Aloke V
dc.date.accessioned2021-07-06T12:22:43Z
dc.date.available2021-07-06T12:22:43Z
dc.date.issued2021-05-27
dc.identifier.urihttp://hdl.handle.net/10713/16126
dc.description.abstractObjective: Reported associations between kidney risk variants (G1 and G2) in APOL1 (apolipoprotein L1), encoding APOL1, and cardiovascular disease have been conflicting. We sought to explore associations of APOL1 risk variants with cause of sudden death using the CVPath Sudden Death Autopsy Registry. Approach and Results: APOL1 haplotypes and causes of sudden death, as determined through autopsy and histopathology, were obtained for 764 Black subjects. Genotyping revealed APOL1 risk alleles in 452 of 764 (59%) subjects with 347 (77%) subjects carrying one risk allele and 105 (23%) subjects harboring 2 risk alleles. APOL1 risk allele carrier status was associated with a significantly increased risk of coronary thrombosis due to plaque rupture, versus noncarriers (odds ratio for rupture, 1.655 [95% CI, 1.079-2.539]; P=0.021). Histological examinations showed coronary plaques in carriers of 2 APOL1 risk alleles had larger necrotic cores compared with noncarriers (necrotic core area/total plaque area: 46.79%±6.47% versus 20.57%±5.11%; P=0.0343 in ruptured plaques, and 41.48%±7.49% versus 18.93%±3.97%; P=0.0342 in nonruptured plaques), and immunohistochemical and immunofluorescent staining revealed APOL1-positive areas localized primarily to the necrotic core. Conclusions: APOL1 risk alleles were independently associated with an increased risk of thrombotic coronary death due to plaque rupture. Our results suggest that carriers of both 1 and 2 APOL1 risk alleles have greater accumulation of APOL1 protein within culprit plaques and greater necrotic core sizes than noncarriers. These findings suggest that APOL1 plays a role in determining plaque stability. © 2021 Lippincott Williams and Wilkins. All rights reserved.en_US
dc.description.urihttps://doi.org/10.1161/ATVBAHA.120.315788en_US
dc.language.isoenen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.relation.ispartofArteriosclerosis, Thrombosis, and Vascular Biologyen_US
dc.subjectapolipoproteinen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectcoronary artery diseaseen_US
dc.subjectkidneyen_US
dc.subjectplaque, atheroscleroticen_US
dc.titleAPOL1 Genetic Variants Are Associated With Increased Risk of Coronary Atherosclerotic Plaque Rupture in the Black Populationen_US
dc.typeArticleen_US
dc.identifier.doi10.1161/ATVBAHA.120.315788
dc.identifier.pmid34039022
dc.source.volume41
dc.source.issue7
dc.source.beginpage2201
dc.source.endpage2214
dc.source.countryUnited States


This item appears in the following Collection(s)

Show simple item record