Current Strategies and Potential Prospects of Nanomedicine-Mediated Therapy in Inflammatory Bowel Disease
Date
2021-06-23Journal
International Journal of NanomedicinePublisher
Dove PressType
Article
Metadata
Show full item recordAbstract
Inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis are highly debilitating. IBDs are associated with the imbalance of inflammatory mediators within the inflamed bowel. Conventional drugs for IBD treatment include anti-inflammatory medications and immune suppressants. However, they suffer from a lack of bioavailability and high dose-induced systemic side effects. Nanoparticle (NP)-derived therapy improves therapeutic efficacy and increases targeting specificity. Recent studies have shown that nanomedicines, based on bowel disease's pathophysiology, are a fast-growing field. NPs can prolong the circulation period and reduce side effects by improving drug encapsulation and targeted delivery. Here, this review summarizes various IBD therapies with a focus on NP-derived applications, whereas their challenges and future perspectives have also been discussed.Rights/Terms
© 2021 Chen et al.Identifier to cite or link to this item
http://hdl.handle.net/10713/16125ae974a485f413a2113503eed53cd6c53
10.2147/IJN.S310952
Scopus Count
Collections
Related articles
- Nanoparticle-Mediated Drug Delivery Systems For The Treatment Of IBD: Current Perspectives.
- Authors: Yang C, Merlin D
- Issue date: 2019
- The future of nanomedicine in optimising the treatment of inflammatory bowel disease.
- Authors: Mohan LJ, Daly JS, Ryan BM, Ramtoola Z
- Issue date: 2019 Jan
- Nanomedicine and drug delivery strategies for treatment of inflammatory bowel disease.
- Authors: Takedatsu H, Mitsuyama K, Torimura T
- Issue date: 2015 Oct 28
- Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease.
- Authors: Li DF, Yang MF, Xu HM, Zhu MZ, Zhang Y, Tian CM, Nie YQ, Wang JY, Liang YJ, Yao J, Wang LS
- Issue date: 2022 Aug 10
- Application of Polymeric Nano-Materials in Management of Inflammatory Bowel Disease.
- Authors: Minakshi P, Kumar R, Ghosh M, Brar B, Barnela M, Lakhani P
- Issue date: 2020