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dc.contributor.authorNovotny, Laura A
dc.contributor.authorEvans, John Grayson
dc.contributor.authorSu, Lishan
dc.contributor.authorGuo, Haitao
dc.contributor.authorMeissner, Eric G
dc.date.accessioned2021-07-06T12:14:20Z
dc.date.available2021-07-06T12:14:20Z
dc.date.issued2021-06-09
dc.identifier.urihttp://hdl.handle.net/10713/16124
dc.description.abstractHepatitis B virus (HBV) chronically infects over 250 million people worldwide and causes nearly 1 million deaths per year due to cirrhosis and liver cancer. Approved treatments for chronic infection include injectable type-I interferons and nucleos(t)ide reverse transcriptase inhibitors. A small minority of patients achieve seroclearance after treatment with type-I interferons, defined as sustained absence of detectable HBV DNA and surface antigen (HBsAg) antigenemia. However, type-I interferons cause significant side effects, are costly, must be administered for months, and most patients have viral rebound or non-response. Nucleos(t)ide reverse transcriptase inhibitors reduce HBV viral load and improve liver-related outcomes, but do not lower HBsAg levels or impart seroclearance. Thus, new therapeutics are urgently needed. Lambda interferons (IFNLs) have been tested as an alternative strategy to stimulate host antiviral pathways to treat HBV infection. IFNLs comprise an evolutionarily conserved innate immune pathway and have cell-type specific activity on hepatocytes, other epithelial cells found at mucosal surfaces, and some immune cells due to restricted cellular expression of the IFNL receptor. This article will review work that examined expression of IFNLs during acute and chronic HBV infection, the impact of IFNLs on HBV replication in vitro and in vivo, the association of polymorphisms in IFNL genes with clinical outcomes, and the therapeutic evaluation of IFNLs for the treatment of chronic HBV infection. © 2021 by the authors.en_US
dc.description.urihttps://doi.org/10.3390/v13061090en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofVirusesen_US
dc.subjecthepatitis B virusen_US
dc.subjectinnate immunityen_US
dc.subjectinterferon lambdaen_US
dc.subjectseroclearanceen_US
dc.titleReview of Lambda Interferons in Hepatitis B Virus Infection: Outcomes and Therapeutic Strategiesen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/v13061090
dc.identifier.pmid34207487
dc.source.volume13
dc.source.issue6
dc.source.countryUnited States
dc.source.countrySwitzerland


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