Show simple item record

dc.contributor.authorWang, Zheng
dc.contributor.authorYang, Ge
dc.contributor.authorRen, Biao
dc.contributor.authorGao, Yuan
dc.contributor.authorPeng, Xian
dc.contributor.authorLi, Mingyun
dc.contributor.authorH K Xu, Hockin
dc.contributor.authorHan, Qi
dc.contributor.authorLi, Jiyao
dc.contributor.authorZhou, Xuedong
dc.contributor.authorCheng, Lei
dc.date.accessioned2021-07-06T12:10:01Z
dc.date.available2021-07-06T12:10:01Z
dc.date.issued2021-06-18
dc.identifier.urihttp://hdl.handle.net/10713/16123
dc.description.abstractThe infection of Enterococcus faecalis and its interacting microorganisms in the root canal could cause persistent apical periodontitis (AP). Antibacterial root canal sealer has favorable prospects to inhibit biofilms. The purpose of this study was to investigated the antibacterial effect of root canal sealer containing dimethylaminododecyl methacrylate (DMADDM) on persistent AP in beagle dogs for the first time. Persistent AP was established by a two-step infection with Enterococcus faecalis and multi-bacteria (Enterococcus faecalis, Lactobacillus acidophilus, Actinomycesnaeslundii, Streptococcus gordonii). Root canal sealer containing DMADDM (0%, 1.25%, 2.5%) was used to complete root canal filling. The volume of lesions and inflammatory grade in the apical area were evaluated by cone beam computer tomography (CBCT) and hematoxylin-eosin staining. Both Enterococcus-faecalis- and multi-bacteria-induced persistent AP caused severe apical destruction, and there were no significant differences in pathogenicity between them. DMADDM-modified sealer significantly reduced the volume of periapical lesion and inflammatory grade compared with the control group, among them, the therapeutic effect of the 2.5% group was better than the 1.25% group. In addition, E.faecalis-induced reinfection was more sensitive to the 2.5% group than multi-bacteria reinfection. This study shows that root canal sealer containing DMADDM had a remarkable therapeutic effect on persistent AP, especially on E. faecalis-induced reinfection.en_US
dc.description.urihttps://doi.org/10.3390/antibiotics10060741en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofAntibiotics (Basel, Switzerland)en_US
dc.subjectEnterococcus faecalisen_US
dc.subjectbeagle dogsen_US
dc.subjectdimethylaminododecyl methacrylateen_US
dc.subjectpersistent apical periodontitisen_US
dc.subjectroot canal sealeren_US
dc.titleEffect of Antibacterial Root Canal Sealer on Persistent Apical Periodontitisen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/antibiotics10060741
dc.identifier.pmid34207470
dc.source.volume10
dc.source.issue6
dc.source.countrySwitzerland


This item appears in the following Collection(s)

Show simple item record