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dc.contributor.authorJiang, Yinan
dc.contributor.authorGuo, Yichen
dc.contributor.authorHao, Jinjin
dc.contributor.authorGuenter, Rachael
dc.contributor.authorLathia, Justin
dc.contributor.authorBeck, Adam W
dc.contributor.authorHattaway, Reagan
dc.contributor.authorHurst, Douglas
dc.contributor.authorWang, Qiming Jane
dc.contributor.authorLiu, Yehe
dc.contributor.authorCao, Qi
dc.contributor.authorKrontiras, Helen
dc.contributor.authorChen, Herbert
dc.contributor.authorSilverstein, Roy
dc.contributor.authorRen, Bin
dc.date.accessioned2021-07-01T18:50:10Z
dc.date.available2021-07-01T18:50:10Z
dc.date.issued2021-06-24
dc.identifier.urihttp://hdl.handle.net/10713/16119
dc.description.abstractBreast cancer stem cells (BCSCs) are essential for cancer growth, metastasis and recurrence. The regulatory mechanisms of BCSC interactions with the vascular niche within the tumor microenvironment (TME) and their self-renewal are currently under extensive investigation. We have demonstrated the existence of an arteriolar niche in the TME of human BC tissues. Intriguingly, BCSCs tend to be enriched within the arteriolar niche in human estrogen receptor positive (ER+) BC and bi-directionally interact with arteriolar endothelial cells (ECs). Mechanistically, this interaction is driven by the lysophosphatidic acid (LPA)/protein kinase D (PKD-1) signaling pathway, which promotes both arteriolar differentiation of ECs and self-renewal of CSCs likely via differential regulation of CD36 transcription. This study indicates that CSCs may enjoy blood perfusion to maintain their stemness features. Targeting the LPA/PKD-1 -CD36 signaling pathway may have therapeutic potential to curb tumor progression by disrupting the arteriolar niche and effectively eliminating CSCs.en_US
dc.description.urihttps://doi.org/10.1038/s42003-021-02308-6en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofCommunications Biologyen_US
dc.subjectarteriolar nicheen_US
dc.subjectbreast cancer stem cellsen_US
dc.subject.meshBreast Neoplasmsen_US
dc.subject.meshCell Self Renewalen_US
dc.subject.meshLysophospholipidsen_US
dc.subject.meshProtein Kinase Den_US
dc.subject.meshSignal Transductionen_US
dc.titleDevelopment of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signalingen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s42003-021-02308-6
dc.identifier.pmid34168243
dc.source.volume4
dc.source.issue1
dc.source.beginpage780
dc.source.endpage
dc.source.countryEngland


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