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dc.contributor.authorJhun, Mina-A
dc.contributor.authorMendelson, Michael
dc.contributor.authorWilson, Rory
dc.contributor.authorGondalia, Rahul
dc.contributor.authorJoehanes, Roby
dc.contributor.authorSalfati, Elias
dc.contributor.authorZhao, Xiaoping
dc.contributor.authorBraun, Kim Valeska Emilie
dc.contributor.authorDo, Anh Nguyet
dc.contributor.authorHedman, Åsa K
dc.contributor.authorZhang, Tao
dc.contributor.authorCarnero-Montoro, Elena
dc.contributor.authorShen, Jincheng
dc.contributor.authorBartz, Traci M
dc.contributor.authorBrody, Jennifer A
dc.contributor.authorMontasser, May E
dc.contributor.authorO'Connell, Jeff R
dc.contributor.authorYao, Chen
dc.contributor.authorXia, Rui
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorGrove, Megan
dc.contributor.authorGuan, Weihua
dc.contributor.authorLiliane, Pfeiffer
dc.contributor.authorSingmann, Paula
dc.contributor.authorMüller-Nurasyid, Martina
dc.contributor.authorMeitinger, Thomas
dc.contributor.authorGieger, Christian
dc.contributor.authorPeters, Annette
dc.contributor.authorZhao, Wei
dc.contributor.authorWare, Erin B
dc.contributor.authorSmith, Jennifer A
dc.contributor.authorDhana, Klodian
dc.contributor.authorvan Meurs, Joyce
dc.contributor.authorUitterlinden, Andre
dc.contributor.authorIkram, Mohammad Arfan
dc.contributor.authorGhanbari, Mohsen
dc.contributor.authorZhi, Deugi
dc.contributor.authorGustafsson, Stefan
dc.contributor.authorLind, Lars
dc.contributor.authorLi, Shengxu
dc.contributor.authorSun, Dianjianyi
dc.contributor.authorSpector, Tim D
dc.contributor.authorChen, Yii-Der Ida
dc.contributor.authorDamcott, Coleen
dc.contributor.authorShuldiner, Alan R
dc.contributor.authorAbsher, Devin M
dc.contributor.authorHorvath, Steve
dc.contributor.authorTsao, Philip S
dc.contributor.authorKardia, Sharon
dc.contributor.authorPsaty, Bruce M
dc.contributor.authorSotoodehnia, Nona
dc.contributor.authorBell, Jordana T
dc.contributor.authorIngelsson, Erik
dc.contributor.authorChen, Wei
dc.contributor.authorDehghan, Abbas
dc.contributor.authorArnett, Donna K
dc.contributor.authorWaldenberger, Melanie
dc.contributor.authorHou, Lifang
dc.contributor.authorWhitsel, Eric A
dc.contributor.authorBaccarelli, Andrea
dc.contributor.authorLevy, Daniel
dc.contributor.authorFornage, Myriam
dc.contributor.authorIrvin, Marguerite R
dc.contributor.authorAssimes, Themistocles L
dc.date.accessioned2021-07-01T18:27:58Z
dc.date.available2021-07-01T18:27:58Z
dc.date.issued2021-06-28
dc.identifier.urihttp://hdl.handle.net/10713/16117
dc.descriptionThe original version of this Article contained an error in the spelling of the author Min-A Jhun which was incorrectly given as Mina-A Jhun. This has now been corrected in both the PDF and HTML versions of the Article.
dc.description.abstractHere we examine the association between DNA methylation in circulating leukocytes and blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations through a trans-ethnic meta-analysis. We observe a high concordance in the direction of effects across racial/ethnic groups, a high correlation of effect sizes between high-density lipoprotein and triglycerides, a modest overlap of associations with epigenome-wide association studies of other cardio-metabolic traits, and a largely non-overlap with lipid loci identified to date through genome-wide association studies. Thirty CpGs reached significance in at least 2 racial/ethnic groups including 7 that showed association with the expression of an annotated gene. CpGs annotated to CPT1A showed evidence of being influenced by triglycerides levels. DNA methylation levels of circulating leukocytes show robust and consistent association with blood lipid levels across multiple racial/ethnic groups.en_US
dc.description.urihttps://doi.org/10.1038/s41467-021-23899-yen_US
dc.description.urihttps://doi.org/10.1038/s41467-021-24600-z
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofNature Communicationsen_US
dc.subjectepigenome-wide association studyen_US
dc.subjectmulti-ethnicen_US
dc.subject.meshDNA Methylationen_US
dc.subject.meshLeukocytesen_US
dc.subject.meshLipids--Blooden_US
dc.titleA multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipidsen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41467-021-23899-y
dc.identifier.doi10.1038/s41467-021-24600-z
dc.identifier.pmid34183656
dc.source.volume12
dc.source.issue1
dc.source.beginpage3987
dc.source.endpage
dc.source.countryEngland


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