Show simple item record

dc.contributor.authorNowak, Blazej
dc.contributor.authorRogujski, Piotr
dc.contributor.authorJanowski, Miroslaw
dc.contributor.authorLukomska, Barbara
dc.contributor.authorAndrzejewska, Anna
dc.date.accessioned2021-06-30T15:48:39Z
dc.date.available2021-06-30T15:48:39Z
dc.date.issued2021-06-16
dc.identifier.urihttp://hdl.handle.net/10713/16115
dc.description.abstractMesenchymal stem cells (MSCs) are among the most investigated and applied somatic stem cells in experimental therapies for the regeneration of damaged tissues. Moreover, as it was recently postulated, MSCs may demonstrate anti-tumor properties. Glioblastoma (GBM) is a grade IV central nervous system tumor with no available effective therapy and an inevitably fatal prognosis. Experimental studies utilizing MSCs in GBM treatment resulted in numerous controversies. Native MSCs were shown to exert anti-GBM activity by controlling angiogenesis, regulating cell cycle, and inducing apoptosis. They also were used as sensitizing factors and vehicles delivering various anti-cancer compounds. On the other hand, some experiments revealed significant risks related to MSC-based therapies for GBM, such as enhancement of tumor cell proliferation, invasion, and aggressiveness. The following review elaborates on all mentioned contradictory data and provides a realistic, current clinical perspective on MSCs' potential in GBM treatment.en_US
dc.description.urihttps://doi.org/10.1016/j.bbcan.2021.188582en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofBiochimica et Biophysica Acta. Reviews on Canceren_US
dc.rightsCopyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.en_US
dc.subjectAnti-tumorigenicen_US
dc.subjectGlioblastomaen_US
dc.subjectMesenchymal stem cellsen_US
dc.subjectPro-tumorigenicen_US
dc.subjectStem cell therapyen_US
dc.subjectTherapyen_US
dc.titleMesenchymal stem cells in glioblastoma therapy and progression: How one cell does it allen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bbcan.2021.188582
dc.identifier.pmid34144129
dc.source.volume1876
dc.source.issue1
dc.source.beginpage188582
dc.source.endpage
dc.source.countryNetherlands


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record