• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Mesenchymal stem cells in glioblastoma therapy and progression: How one cell does it all

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Publisher version
    View Source
    Access full-text PDFOpen Access
    View Source
    Check access options
    Check access options
    Author
    Nowak, Blazej
    Rogujski, Piotr
    Janowski, Miroslaw
    Lukomska, Barbara
    Andrzejewska, Anna
    Date
    2021-06-16
    Journal
    Biochimica et Biophysica Acta. Reviews on Cancer
    Publisher
    Elsevier B.V.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1016/j.bbcan.2021.188582
    Abstract
    Mesenchymal stem cells (MSCs) are among the most investigated and applied somatic stem cells in experimental therapies for the regeneration of damaged tissues. Moreover, as it was recently postulated, MSCs may demonstrate anti-tumor properties. Glioblastoma (GBM) is a grade IV central nervous system tumor with no available effective therapy and an inevitably fatal prognosis. Experimental studies utilizing MSCs in GBM treatment resulted in numerous controversies. Native MSCs were shown to exert anti-GBM activity by controlling angiogenesis, regulating cell cycle, and inducing apoptosis. They also were used as sensitizing factors and vehicles delivering various anti-cancer compounds. On the other hand, some experiments revealed significant risks related to MSC-based therapies for GBM, such as enhancement of tumor cell proliferation, invasion, and aggressiveness. The following review elaborates on all mentioned contradictory data and provides a realistic, current clinical perspective on MSCs' potential in GBM treatment.
    Rights/Terms
    Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
    Keyword
    Anti-tumorigenic
    Glioblastoma
    Mesenchymal stem cells
    Pro-tumorigenic
    Stem cell therapy
    Therapy
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/16115
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.bbcan.2021.188582
    Scopus Count
    Collections
    UMB Open Access Articles

    entitlement

    Related articles

    • Umbilical cord blood-derived mesenchymal stem cells inhibit, but adipose tissue-derived mesenchymal stem cells promote, glioblastoma multiforme proliferation.
    • Authors: Akimoto K, Kimura K, Nagano M, Takano S, To'a Salazar G, Yamashita T, Ohneda O
    • Issue date: 2013 May 1
    • Cross talk between mesenchymal and glioblastoma stem cells: Communication beyond controversies.
    • Authors: Bajetto A, Thellung S, Dellacasagrande I, Pagano A, Barbieri F, Florio T
    • Issue date: 2020 Nov
    • Simultaneous impact of atorvastatin and mesenchymal stem cells for glioblastoma multiform suppression in rat glioblastoma multiform model.
    • Authors: Goodarzi A, Khanmohammadi M, Ai A, Khodayari H, Ai A, Farahani MS, Khodayari S, Ebrahimi-Barough S, Mohandesnezhad S, Ai J
    • Issue date: 2020 Oct
    • Tropism of mesenchymal stem cell toward CD133<sup>+</sup> stem cell of glioblastoma in vitro and promote tumor proliferation in vivo.
    • Authors: Pavon LF, Sibov TT, de Souza AV, da Cruz EF, Malheiros SMF, Cabral FR, de Souza JG, Boufleur P, de Oliveira DM, de Toledo SRC, Marti LC, Malheiros JM, Paiva FF, Tannús A, de Oliveira SM, Chudzinski-Tavassi AM, de Paiva Neto MA, Cavalheiro S
    • Issue date: 2018 Nov 9
    • Exploiting tumor-intrinsic signals to induce mesenchymal stem cell-mediated suicide gene therapy to fight malignant glioma.
    • Authors: Li M, Sun S, Dangelmajer S, Zhang Q, Wang J, Hu F, Dong F, Kahlert UD, Zhu M, Lei T
    • Issue date: 2019 Mar 12
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.