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dc.contributor.authorWalczak, Piotr
dc.contributor.authorJanowski, Miroslaw
dc.date.accessioned2021-06-30T15:20:09Z
dc.date.available2021-06-30T15:20:09Z
dc.date.issued2021-05-07
dc.identifier.urihttp://hdl.handle.net/10713/16111
dc.description.abstractCoronavirus disease 2019 (COVID-19) is caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which binds to ectoenzyme angiotensin-converting enzyme 2. It is very contagious and is spreading rapidly around the world. Until now, coronaviruses have mainly been associated with the aerodigestive tract due to the presence of a monobasic cleavage site for the resident transmembrane serine protease 2. Notably, SARS-CoV-2 is equipped with a second, polybasic cleavage site for the ubiquitous furin protease, which may determine the widespread tissue tropism. Furthermore, the terminal sequence of the furin-cleaved spike protein also binds to neuropilin receptors. Clinically, there is enormous variability in the severity of the disease. Severe consequences are seen in a relatively small number of patients, most show moderate symptoms, but asymptomatic cases, especially among young people, drive disease spread. Unfortunately, the number of local infections can quickly build up, causing disease outbreaks suddenly exhausting health services' capacity. Therefore, COVID-19 is dangerous and unpredictable and has become the most serious threat for generations. Here, the latest research on COVID-19 is summarized, including its spread, testing methods, organ-specific complications, the role of comorbidities, long-term consequences, mortality, as well as a new hope for immunity, drugs, and vaccines.en_US
dc.description.urihttps://doi.org/10.1002/gch2.202100004en_US
dc.description.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/pmc8209929/en_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofGlobal Challenges (Hoboken, NJ)en_US
dc.rights© 2021 The Authors. Global Challenges published by Wiley‐VCH GmbH.en_US
dc.subjectCOVID‐19en_US
dc.subjectSARS‐CoV‐2en_US
dc.subjectdrugsen_US
dc.subjectmortalityen_US
dc.subjecttransmissionen_US
dc.subjectvaccinesen_US
dc.subjectvirusesen_US
dc.titleThe COVID-19 Menaceen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/gch2.202100004
dc.identifier.pmid34178377
dc.source.beginpage2100004
dc.source.endpage
dc.source.countryGermany


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