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dc.contributor.authorNiang, Mbayame Nd
dc.contributor.authorSugimoto, Jonathan D
dc.contributor.authorDiallo, Aldiouma
dc.contributor.authorDiarra, Bou
dc.contributor.authorOrtiz, Justin R
dc.contributor.authorLewis, Kristen D C
dc.contributor.authorLafond, Kathryn E
dc.contributor.authorHalloran, M Elizabeth
dc.contributor.authorWiddowson, Marc-Alain
dc.contributor.authorNeuzil, Kathleen M
dc.contributor.authorVictor, John C
dc.date.accessioned2021-06-29T12:27:36Z
dc.date.available2021-06-29T12:27:36Z
dc.date.issued2020-11-09
dc.identifier.urihttp://hdl.handle.net/10713/16107
dc.description.abstractBackground We report results of years 2 and 3 of consecutive cluster-randomized controlled trials of trivalent inactivated influenza vaccine (IIV3) in Senegal. Methods We cluster-randomized (1:1) 20 villages to annual vaccination with IIV3 or inactivated poliovirus vaccine (IPV) of age-eligible residents (6 months–10 years). The primary outcome was total vaccine effectiveness against laboratory-confirmed influenza illness (LCI) among age-eligible children (modified intention-to-treat population [mITT]). Secondary outcomes were indirect (herd protection) and population (overall community) vaccine effectiveness. Results We vaccinated 74% of 12 408 age-eligible children in year 2 (June 2010–April 11) and 74% of 11 988 age-eligible children in year 3 (April 2011–December 2011) with study vaccines. Annual cumulative incidence of LCI was 4.7 (year 2) and 4.2 (year 3) per 100 mITT child vaccinees of IPV villages. In year 2, IIV3 matched circulating influenza strains. The total effectiveness was 52.8% (95% confidence interval [CI], 32.3–67.0), and the population effectiveness was 36.0% (95% CI, 10.2–54.4) against LCI caused by any influenza strain. The indirect effectiveness against LCI by A/H3N2 was 56.4% (95% CI, 39.0–68.9). In year 3, 74% of influenza detections were vaccine-mismatched to circulating B/Yamagata and 24% were vaccine-matched to circulating A/H3N2. The year 3 total effectiveness against LCI was −14.5% (95% CI, −81.2–27.6). Vaccine effectiveness varied by type/subtype of influenza in both years. Conclusions IIV3 was variably effective against influenza illness in Senegalese children, with total and indirect vaccine effectiveness present during the year when all circulating strains matched the IIV3 formulation. Clinical Trials Registration NCT00893906.en_US
dc.description.urihttps://doi.org/10.1093/cid/ciaa1689en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofClinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of Americaen_US
dc.rightsPublished by Oxford University Press for the Infectious Diseases Society of America 2020.en_US
dc.subjectAfricaen_US
dc.subjectchildrenen_US
dc.subjectcluster-randomized trialen_US
dc.subjectinfluenza vaccineen_US
dc.subjectvaccine effectivenessen_US
dc.titleEstimates of Inactivated Influenza Vaccine Effectiveness Among Children in Senegal: Results From 2 Consecutive Cluster-Randomized Controlled Trials in 2010 and 2011en_US
dc.typeArticleen_US
dc.identifier.doi10.1093/cid/ciaa1689
dc.identifier.pmid33165566
dc.source.volume72
dc.source.issue12
dc.source.beginpagee959
dc.source.endpagee969
dc.source.countryUnited States


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