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dc.contributor.authorHensley, Nadia B
dc.contributor.authorMazzeffi, Michael A
dc.date.accessioned2021-06-28T14:34:00Z
dc.date.available2021-06-28T14:34:00Z
dc.date.issued2021-06
dc.identifier.urihttp://hdl.handle.net/10713/16096
dc.description.abstractCryoprecipitate has been the gold standard for treating acquired hypofibrinogenemia in cardiac surgery for nearly 50 years. More recently, fibrinogen concentrate has been used off-label in the United States and is the standard in European countries and Canada to treat the acquired hypofibrinogenemia during cardiac surgery. Fibrinogen concentrate has multiple potential advantages including rapid reconstitution, greater dose predictability, viral inactivation during processing, and reduced transfusion-related adverse events. However, because fibrinogen concentrate lacks the other components contained in the cryoprecipitate, it may not be the "ideal" product for replacing fibrinogen in all cardiac surgical patients, particularly those with longer cardiopulmonary bypass duration. In this Pro-Con commentary article, we discuss the advantages and disadvantages of using fibrinogen concentrate and cryoprecipitate to treat acquired hypofibrinogenemia in cardiac surgical patients.en_US
dc.description.urihttps://doi.org/10.1213/ANE.0000000000005513en_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Healthen_US
dc.relation.ispartofAnesthesia and Analgesiaen_US
dc.rightsCopyright © 2021 International Anesthesia Research Society.en_US
dc.subjectcryoprecipitateen_US
dc.subjectfibrinogen concentrateen_US
dc.subject.meshAfibrinogenemiaen_US
dc.subject.meshCardiac Surgical Proceduresen_US
dc.titlePro-Con Debate: Fibrinogen Concentrate or Cryoprecipitate for Treatment of Acquired Hypofibrinogenemia in Cardiac Surgical Patientsen_US
dc.typeArticleen_US
dc.identifier.doi10.1213/ANE.0000000000005513
dc.identifier.pmid34127586
dc.source.volume133
dc.source.issue1
dc.source.beginpage19
dc.source.endpage28
dc.source.countryUnited States


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