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dc.contributor.authorDoub, James B
dc.contributor.authorNg, Vincent Y
dc.contributor.authorJohnson, Aaron
dc.contributor.authorAmoroso, Anthony
dc.contributor.authorKottilil, Shyamasundaran
dc.contributor.authorWilson, Eleanor
dc.date.accessioned2021-06-25T12:06:50Z
dc.date.available2021-06-25T12:06:50Z
dc.date.issued2021-05-26
dc.identifier.urihttp://hdl.handle.net/10713/16086
dc.description.abstractThe number of arthroplasties conducted annually continues to increase; however, approximately 1%-2% of all knee and hip arthroplasties will become infected. These prosthetic joint infections are costly, difficult to treat, and cause significant morbidity and mortality as a direct result of conventional surgical and medical managements. In this perspective, we discuss factors that make these infections arduous to treat as well as the potential use of adjuvant bacteriophage therapy with debridement, antibiotics, and implant retention surgery to cure these infections without removing the infected prosthesis. We also provide rationale as to why future clinical trials evaluating this novel therapeutic will need to be designed as noninferiority trials, and we compare this approach to 2-stage revision surgery. If bacteriophage therapy continues to show effectiveness, this could revolutionize the treatment of prosthetic joint infections and pioneer new treatments for similar infections.en_US
dc.description.urihttps://doi.org/10.1093/ofid/ofab277en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofOpen Forum Infectious Diseasesen_US
dc.rights© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.en_US
dc.subjectDAIRen_US
dc.subjectarthroplastyen_US
dc.subjectbacteriophage therapyen_US
dc.subjectbiofilmen_US
dc.subjectprosthetic joint infectionen_US
dc.titlePotential Use of Adjuvant Bacteriophage Therapy With Debridement, Antibiotics, and Implant Retention Surgery to Treat Chronic Prosthetic Joint Infectionsen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/ofid/ofab277
dc.identifier.pmid34159220
dc.source.volume8
dc.source.issue6
dc.source.beginpageofab277
dc.source.endpage
dc.source.countryUnited States


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