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dc.contributor.authorMohsin, Shazia S
dc.contributor.authorAbbas, Qalab
dc.contributor.authorChowdhary, Devyani
dc.contributor.authorKhalid, Farah
dc.contributor.authorSheikh, Abdul Sattar
dc.contributor.authorAli Khan, Zuviya Ghazala
dc.contributor.authorAslam, Nadeem
dc.contributor.authorBhatti, Omaima Anis
dc.contributor.authorInam, Maha
dc.contributor.authorSaleem, Ali Faisal
dc.contributor.authorBhutta, Adnan T
dc.date.accessioned2021-06-23T16:39:48Z
dc.date.available2021-06-23T16:39:48Z
dc.date.issued2021-06-21
dc.identifier.urihttp://hdl.handle.net/10713/16074
dc.description.abstractObjectives: To determine clinical, laboratory features and outcomes of Multisystem Inflammatory Syndrome in children (MIS-C) and its comparison with historic Kawasaki Disease (KD) and Viral Myocarditis (VM) cohorts. Methods: All children (1 month- 18 years) who fulfilled the World Health Organization criteria of MIS-C presenting to two tertiary care centers in Karachi from May 2020 till August 31st were included. KD and VM admitted to one of the study centers in the last five years prior to this pandemic, was compared to MIS-C. Results: Thirty children with median age of 24 (interquartile range (IQR)1-192) months met the criteria for MIS-C. Three phenotypes were identified, 12 patients (40%) with KD, ten (33%) VM and eight (26%) had features of TSS. Echocardiography showed coronary involvement in 10 (33%), and moderate to severe Left Ventricular dysfunction in 10 (33%) patients. Steroids and intravenous immunoglobulins (IVIG) were administered to 24 (80%) and 12 (41%) patients respectively while 7 (23%) received both. Overall, 20% children expired. During the last five years, 30 and 47 children were diagnosed with KD and VM, respectively. Their comparison with MIS-C group showed lymphopenia, thrombocytosis, and higher CRP as well as more frequent atypical presentation in MIS-C KD group with less coronary involvement. The MIS-C VM was more likely to present with fulminant myocarditis. Conclusions: Our MIS-C cohort is younger with higher mortality compared to previous reports. MIS-C is distinct from historic cohorts of KD and VM in both in clinical features and outcomes.en_US
dc.description.urihttps://doi.org/10.1371/journal.pone.0253625en_US
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS ONEen_US
dc.subjectmultisystem inflammatory syndrome (MIS-C)en_US
dc.subject.lcshChildrenen_US
dc.subject.meshCOVID-19en_US
dc.subject.meshPakistanen_US
dc.titleMultisystem inflammatory syndrome (MIS-C) in Pakistani children: A description of the phenotypes and comparison with historical cohorts of children with Kawasaki disease and myocarditisen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pone.0253625
dc.identifier.pmid34153080
dc.source.volume16
dc.source.issue6
dc.source.beginpagee0253625
dc.source.endpage
dc.source.countryUnited States


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