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dc.contributor.authorOliva Chávez, Adela S
dc.contributor.authorWang, Xiaowei
dc.contributor.authorMarnin, Liron
dc.contributor.authorArcher, Nathan K
dc.contributor.authorHammond, Holly L
dc.contributor.authorCarroll, Erin E McClure
dc.contributor.authorShaw, Dana K
dc.contributor.authorTully, Brenden G
dc.contributor.authorBuskirk, Amanda D
dc.contributor.authorFord, Shelby L
dc.contributor.authorButler, L Rainer
dc.contributor.authorShahi, Preeti
dc.contributor.authorMorozova, Kateryna
dc.contributor.authorClement, Cristina C
dc.contributor.authorLawres, Lauren
dc.contributor.authorNeal, Anya J O'
dc.contributor.authorMamoun, Choukri Ben
dc.contributor.authorMason, Kathleen L
dc.contributor.authorHobbs, Brandi E
dc.contributor.authorScoles, Glen A
dc.contributor.authorBarry, Eileen M
dc.contributor.authorSonenshine, Daniel E
dc.contributor.authorPal, Utpal
dc.contributor.authorValenzuela, Jesus G
dc.contributor.authorSztein, Marcelo B
dc.contributor.authorPasetti, Marcela F
dc.contributor.authorLevin, Michael L
dc.contributor.authorKotsyfakis, Michail
dc.contributor.authorJay, Steven M
dc.contributor.authorHuntley, Jason F
dc.contributor.authorMiller, Lloyd S
dc.contributor.authorSantambrogio, Laura
dc.contributor.authorPedra, Joao H F
dc.date.accessioned2021-06-23T14:36:25Z
dc.date.available2021-06-23T14:36:25Z
dc.date.issued2021-06-17
dc.identifier.urihttp://hdl.handle.net/10713/16067
dc.description.abstractExtracellular vesicles are thought to facilitate pathogen transmission from arthropods to humans and other animals. Here, we reveal that pathogen spreading from arthropods to the mammalian host is multifaceted. Extracellular vesicles from Ixodes scapularis enable tick feeding and promote infection of the mildly virulent rickettsial agent Anaplasma phagocytophilum through the SNARE proteins Vamp33 and Synaptobrevin 2 and dendritic epidermal T cells. However, extracellular vesicles from the tick Dermacentor andersoni mitigate microbial spreading caused by the lethal pathogen Francisella tularensis. Collectively, we establish that tick extracellular vesicles foster distinct outcomes of bacterial infection and assist in vector feeding by acting on skin immunity. Thus, the biology of arthropods should be taken into consideration when developing strategies to control vector-borne diseases.en_US
dc.description.urihttps://doi.org/10.1038/s41467-021-23900-8en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofNature Communicationsen_US
dc.subject.meshArthropod Vectorsen_US
dc.subject.meshExtracellular Vesiclesen_US
dc.subject.meshTick-Borne Diseasesen_US
dc.subject.meshTicksen_US
dc.titleTick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infectionen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41467-021-23900-8
dc.identifier.pmid34140472
dc.source.volume12
dc.source.issue1
dc.source.beginpage3696
dc.source.endpage
dc.source.countryUnited States
dc.source.countryEngland


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