• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Evaluation of post-introduction COVID-19 vaccine effectiveness: Summary of interim guidance of the World Health Organization

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Publisher version
    View Source
    Access full-text PDFOpen Access
    View Source
    Check access options
    Check access options
    Author
    Patel, Minal K
    Bergeri, Isabel
    Bresee, Joseph S
    Cowling, Benjamin J
    Crowcroft, Natasha S
    Fahmy, Kamal
    Hirve, Siddhivinayak
    Kang, Gagandeep
    Katz, Mark A
    Lanata, Claudio F
    L'Azou Jackson, Maïna
    Joshi, Sudhir
    Lipsitch, Marc
    Mwenda, Jason M
    Nogareda, Francisco
    Orenstein, Walter A
    Ortiz, Justin R
    Pebody, Richard
    Schrag, Stephanie J
    Smith, Peter G
    Srikantiah, Padmini
    Subissi, Lorenzo
    Valenciano, Marta
    Vaughn, David W
    Verani, Jennifer R
    Wilder-Smith, Annelies
    Feikin, Daniel R
    Show allShow less

    Date
    2021-06-01
    Journal
    Vaccine
    Publisher
    Elsevier Ltd.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1016/j.vaccine.2021.05.099
    Abstract
    Phase 3 randomized-controlled trials have provided promising results of COVID-19 vaccine efficacy, ranging from 50 to 95% against symptomatic disease as the primary endpoints, resulting in emergency use authorization/listing for several vaccines. However, given the short duration of follow-up during the clinical trials, strict eligibility criteria, emerging variants of concern, and the changing epidemiology of the pandemic, many questions still remain unanswered regarding vaccine performance. Post-introduction vaccine effectiveness evaluations can help us to understand the vaccine's effect on reducing infection and disease when used in real-world conditions. They can also address important questions that were either not studied or were incompletely studied in the trials and that will inform evolving vaccine policy, including assessment of the duration of effectiveness; effectiveness in key subpopulations, such as the very old or immunocompromised; against severe disease and death due to COVID-19; against emerging SARS-CoV-2 variants of concern; and with different vaccination schedules, such as number of doses and varying dosing intervals. WHO convened an expert panel to develop interim best practice guidance for COVID-19 vaccine effectiveness evaluations. We present a summary of the interim guidance, including discussion of different study designs, priority outcomes to evaluate, potential biases, existing surveillance platforms that can be used, and recommendations for reporting results.
    Rights/Terms
    Copyright © 2021.
    Keyword
    COVID-19
    Vaccination
    Vaccine effectiveness
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/16056
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.vaccine.2021.05.099
    Scopus Count
    Collections
    UMB Coronavirus Publications
    UMB Open Access Articles

    entitlement

    Related articles

    • A randomized, double-blind, placebo-controlled phase III clinical trial to evaluate the efficacy and safety of SARS-CoV-2 vaccine (inactivated, Vero cell): a structured summary of a study protocol for a randomised controlled trial.
    • Authors: Akova M, Unal S
    • Issue date: 2021 Apr 13
    • COVID-19 vaccines: concerns beyond protective efficacy and safety.
    • Authors: Lai CC, Chen IT, Chao CM, Lee PI, Ko WC, Hsueh PR
    • Issue date: 2021 Aug
    • Emerging Variants of SARS-CoV-2 And Novel Therapeutics Against Coronavirus (COVID-19)
    • Authors: Aleem A, Akbar Samad AB, Slenker AK
    • Issue date: 2022 Jan
    • A prospective, randomized, single-blinded, crossover trial to investigate the effect of a wearable device in addition to a daily symptom diary for the remote early detection of SARS-CoV-2 infections (COVID-RED): a structured summary of a study protocol for a randomized controlled trial.
    • Authors: Brakenhoff TB, Franks B, Goodale BM, van de Wijgert J, Montes S, Veen D, Fredslund EK, Rispens T, Risch L, Dowling AV, Folarin AA, Bruijning P, Dobson R, Heikamp T, Klaver P, Cronin M, Grobbee DE, COVID-RED Consortium.
    • Issue date: 2021 Jun 22
    • Double-Blind, Randomized, Placebo-Controlled Phase III Clinical Trial to Evaluate the Efficacy and Safety of treating Healthcare Professionals with the Adsorbed COVID-19 (Inactivated) Vaccine Manufactured by Sinovac - PROFISCOV: A structured summary of a study protocol for a randomised controlled trial.
    • Authors: Palacios R, Patiño EG, de Oliveira Piorelli R, Conde MTRP, Batista AP, Zeng G, Xin Q, Kallas EG, Flores J, Ockenhouse CF, Gast C
    • Issue date: 2020 Oct 15
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.